| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Wolves | 110 | Thunder | 100 |
| November | 5, 2021 | Clippers | 120 | Thunder | 108 |
| November | 7, 2021 | Thunder | 101 | Lakers | 118 |
| November | 8, 2021 | Thunder | 107 | Rockets | 106 |
| November | 9, 2021 | Nuggets | 106 | Thunder | 120 |
| November | 12, 2021 | Spurs | 142 | Thunder | 105 |
| November | 15, 2021 | Thunder | 112 | Raptors | 127 |
| November | 18, 2021 | Thunder | 109 | Bucks | 115 |
| November | 20, 2021 | Thunder | 76 | Bulls | 105 |
| November | 23, 2021 | Thunder | 115 | Magic | 129 |
| November | 25, 2021 | Thunder | 115 | Cavaliers | 126 |
| November | 28, 2021 | Thunder | 100 | Trailblazers | 77 |
| November | 30, 2021 | Nets | 103 | Thunder | 95 |
| December | 1, 2021 | Pistons | 105 | Thunder | 110 |
| December | 3, 2021 | Thunder | 113 | Warriors | 126 |
| December | 6, 2021 | Hornets | 99 | Thunder | 104 |
| December | 9, 2021 | Raptors | 109 | Thunder | 96 |
| December | 12, 2021 | Thunder | 91 | 76ers | 94 |
| December | 14, 2021 | Thunder | 123 | Celtics | 98 |
| December | 17, 2021 | Wizards | 89 | Thunder | 102 |
| December | 18, 2021 | Hawks | 118 | Thunder | 105 |
| December | 20, 2021 | Thunder | 112 | Pelicans | 105 |
| December | 22, 2021 | Lakers | 119 | Thunder | 135 |
| December | 25, 2021 | Warriors | 134 | Thunder | 118 |
| December | 27, 2021 | Jazz | 113 | Thunder | 107 |
| December | 29, 2021 | Thunder | 119 | Grizzlies | 123 |
| December | 31, 2021 | Mavericks | 107 | Thunder | 100 |
| January | 2, 2022 | Thunder | 117 | Suns | 137 |
| January | 4, 2022 | Celtics | 115 | Thunder | 119 |
| January | 6, 2022 | Thunder | 117 | Clippers | 142 |
| January | 8, 2022 | Rockets | 88 | Thunder | 103 |
| January | 10, 2022 | Thunder | 87 | Pelicans | 107 |
| January | 12, 2022 | 76ers | 83 | Thunder | 96 |
| January | 15, 2022 | Heat | 98 | Thunder | 87 |
| January | 16, 2022 | Pacers | 115 | Thunder | 118 |
| January | 19, 2022 | Thunder | 125 | Jazz | 115 |
| January | 20, 2022 | Thunder | 110 | Spurs | 131 |
| January | 23, 2022 | Magic | 118 | Thunder | 128 |
| January | 25, 2022 | Thunder | 95 | Mavericks | 114 |
| January | 28, 2022 | Suns | 104 | Thunder | 116 |
| January | 30, 2022 | Thunder | 106 | Pacers | 116 |
| February | 2, 2022 | Wolves | 114 | Thunder | 105 |
| February | 5, 2022 | Thunder | 84 | Knicks | 95 |
| February | 7, 2022 | Thunder | 106 | Nets | 121 |
| February | 14, 2022 | Thunder | 131 | Nuggets | 120 |
| February | 16, 2022 | Bucks | 134 | Thunder | 103 |
| February | 19, 2022 | Thunder | 93 | Hornets | 133 |
| February | 22, 2022 | Jazz | 96 | Thunder | 151 |
| February | 25, 2022 | Thunder | 136 | Clippers | 117 |
| February | 28, 2022 | Grizzlies | 150 | Thunder | 151 |
| March | 2, 2022 | Thunder | 115 | Wizards | 127 |
| March | 4, 2022 | Thunder | 78 | Heat | 115 |
| March | 5, 2022 | Thunder | 92 | Pistons | 103 |
| March | 7, 2022 | Lakers | 106 | Thunder | 118 |
| March | 10, 2022 | Mavericks | 106 | Thunder | 123 |
| March | 12, 2022 | Thunder | 89 | Hawks | 114 |
| March | 15, 2022 | Thunder | 78 | Rockets | 89 |
| March | 18, 2022 | Thunder | 93 | Spurs | 103 |
| March | 21, 2022 | Pelicans | 93 | Thunder | 121 |
| March | 22, 2022 | Thunder | 102 | Wolves | 116 |
| March | 24, 2022 | Clippers | 125 | Thunder | 104 |
| March | 27, 2022 | Cavaliers | 124 | Thunder | 115 |
| March | 29, 2022 | Thunder | 130 | Kings | 139 |
| March | 31, 2022 | Thunder | 114 | Nuggets | 120 |
| April | 3, 2022 | Kings | 105 | Thunder | 115 |
| April | 4, 2022 | Thunder | 127 | Lakers | 117 |
| April | 6, 2022 | Thunder | 92 | Mavericks | 119 |
| April | 9, 2022 | Trailblazers | 77 | Thunder | 102 |
| April | 11, 2022 | Bulls | 73 | Thunder | 121 |
| April | 13, 2022 | Nuggets | 101 | Thunder | 100 |
| April | 14, 2022 | Pelicans | 89 | Thunder | 123 |
| April | 16, 2022 | Kings | 119 | Thunder | 121 |
| April | 18, 2022 | Rockets | 99 | Thunder | 90 |
| April | 19, 2022 | Thunder | 89 | Trailblazers | 104 |
| April | 21, 2022 | Thunder | 92 | Kings | 122 |
| April | 22, 2022 | Suns | 88 | Thunder | 111 |
| April | 24, 2022 | Thunder | 89 | Wolves | 112 |
| April | 25, 2022 | Thunder | 109 | Jazz | 100 |
| April | 27, 2022 | Knicks | 79 | Thunder | 101 |
| April | 28, 2022 | Grizzlies | 101 | Thunder | 82 |
| April | 30, 2022 | Warriors | 123 | Thunder | 118 |
| May | 1, 2022 | Thunder | 122 | Suns | 107 |