| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Rockets | 106 | Spurs | 109 |
| November | 3, 2021 | Rockets | 91 | Mavericks | 95 |
| November | 6, 2021 | Pelicans | 99 | Rockets | 112 |
| November | 8, 2021 | Thunder | 107 | Rockets | 106 |
| November | 11, 2021 | Rockets | 85 | Nuggets | 81 |
| November | 13, 2021 | Pacers | 112 | Rockets | 103 |
| November | 14, 2021 | Kings | 80 | Rockets | 110 |
| November | 17, 2021 | Rockets | 114 | Bucks | 131 |
| November | 19, 2021 | Rockets | 104 | Wizards | 97 |
| November | 22, 2021 | Rockets | 109 | Hornets | 112 |
| November | 24, 2021 | Rockets | 87 | Bulls | 108 |
| November | 26, 2021 | Rockets | 117 | Suns | 90 |
| November | 28, 2021 | Grizzlies | 104 | Rockets | 95 |
| November | 30, 2021 | Rockets | 83 | Pelicans | 85 |
| December | 1, 2021 | Rockets | 103 | Jazz | 100 |
| December | 3, 2021 | Rockets | 101 | Wolves | 118 |
| December | 6, 2021 | Hawks | 107 | Rockets | 103 |
| December | 8, 2021 | Clippers | 83 | Rockets | 111 |
| December | 9, 2021 | Celtics | 105 | Rockets | 114 |
| December | 11, 2021 | Rockets | 98 | Trailblazers | 81 |
| December | 12, 2021 | Spurs | 112 | Rockets | 106 |
| December | 14, 2021 | Nuggets | 76 | Rockets | 105 |
| December | 17, 2021 | Rockets | 87 | 76ers | 83 |
| December | 18, 2021 | Rockets | 82 | Knicks | 96 |
| December | 21, 2021 | Rockets | 105 | Cavaliers | 89 |
| December | 23, 2021 | Heat | 102 | Rockets | 80 |
| December | 26, 2021 | Suns | 88 | Rockets | 104 |
| December | 29, 2021 | Rockets | 88 | Pistons | 83 |
| December | 31, 2021 | Rockets | 121 | Pacers | 101 |
| January | 1, 2022 | Warriors | 110 | Rockets | 101 |
| January | 3, 2022 | Magic | 103 | Rockets | 108 |
| January | 6, 2022 | Rockets | 106 | Lakers | 116 |
| January | 8, 2022 | Rockets | 88 | Thunder | 103 |
| January | 11, 2022 | Rockets | 96 | Spurs | 92 |
| January | 13, 2022 | Nuggets | 87 | Rockets | 109 |
| January | 15, 2022 | Rockets | 87 | Nets | 90 |
| January | 16, 2022 | Rockets | 106 | Celtics | 108 |
| January | 18, 2022 | Rockets | 100 | Warriors | 104 |
| January | 20, 2022 | Mavericks | 114 | Rockets | 106 |
| January | 21, 2022 | Raptors | 109 | Rockets | 92 |
| January | 23, 2022 | Bucks | 105 | Rockets | 95 |
| January | 25, 2022 | Rockets | 94 | Trailblazers | 75 |
| January | 27, 2022 | Lakers | 96 | Rockets | 135 |
| January | 29, 2022 | Hornets | 93 | Rockets | 94 |
| January | 31, 2022 | Clippers | 94 | Rockets | 114 |
| February | 2, 2022 | Rockets | 99 | Warriors | 115 |
| February | 5, 2022 | Rockets | 118 | Magic | 125 |
| February | 6, 2022 | Rockets | 112 | Raptors | 121 |
| February | 13, 2022 | Pistons | 87 | Rockets | 88 |
| February | 16, 2022 | Wizards | 69 | Rockets | 85 |
| February | 19, 2022 | Rockets | 75 | Mavericks | 88 |
| February | 21, 2022 | Rockets | 102 | Grizzlies | 105 |
| February | 23, 2022 | Knicks | 104 | Rockets | 84 |
| February | 25, 2022 | Nets | 66 | Rockets | 95 |
| February | 27, 2022 | Spurs | 98 | Rockets | 102 |
| March | 2, 2022 | Rockets | 108 | Clippers | 102 |
| March | 3, 2022 | Trailblazers | 94 | Rockets | 104 |
| March | 6, 2022 | Rockets | 72 | Heat | 83 |
| March | 9, 2022 | Rockets | 82 | Hawks | 102 |
| March | 11, 2022 | Jazz | 87 | Rockets | 90 |
| March | 13, 2022 | Rockets | 91 | Wolves | 104 |
| March | 15, 2022 | Thunder | 78 | Rockets | 89 |
| March | 17, 2022 | Cavaliers | 105 | Rockets | 103 |
| March | 18, 2022 | Rockets | 105 | Nuggets | 73 |
| March | 21, 2022 | Kings | 113 | Rockets | 107 |
| March | 24, 2022 | Warriors | 112 | Rockets | 106 |
| March | 27, 2022 | Rockets | 108 | Lakers | 125 |
| March | 30, 2022 | 76ers | 83 | Rockets | 95 |
| April | 1, 2022 | Rockets | 117 | Pelicans | 88 |
| April | 2, 2022 | Lakers | 107 | Rockets | 105 |
| April | 4, 2022 | Bulls | 79 | Rockets | 78 |
| April | 7, 2022 | Rockets | 110 | Kings | 107 |
| April | 9, 2022 | Suns | 79 | Rockets | 108 |
| April | 12, 2022 | Mavericks | 108 | Rockets | 96 |
| April | 15, 2022 | Wolves | 111 | Rockets | 120 |
| April | 18, 2022 | Rockets | 99 | Thunder | 90 |
| April | 20, 2022 | Jazz | 99 | Rockets | 89 |
| April | 22, 2022 | Pelicans | 92 | Rockets | 98 |
| April | 23, 2022 | Rockets | 97 | Grizzlies | 115 |
| April | 25, 2022 | Trailblazers | 82 | Rockets | 105 |
| April | 28, 2022 | Rockets | 131 | Suns | 76 |
| May | 1, 2022 | Rockets | 114 | Jazz | 77 |
| Post | 1, 2022 | Rockets | 96 | Wolves | 108 |
| Post | 2, 2022 | Rockets | 102 | Wolves | 100 |
| Post | 3, 2022 | Wolves | 63 | Rockets | 82 |
| Post | 4, 2022 | Wolves | 107 | Rockets | 98 |
| Post | 5, 2022 | Rockets | 79 | Wolves | 91 |
| Post | 6, 2022 | Wolves | 96 | Rockets | 97 |
| Post | 7, 2022 | Rockets | 100 | Wolves | 108 |