| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Magic | 112 | Raptors | 132 |
| November | 6, 2021 | Bulls | 95 | Raptors | 116 |
| November | 7, 2021 | Mavericks | 105 | Raptors | 116 |
| November | 10, 2021 | Hawks | 101 | Raptors | 100 |
| November | 11, 2021 | Raptors | 126 | Warriors | 111 |
| November | 13, 2021 | Pelicans | 87 | Raptors | 93 |
| November | 15, 2021 | Thunder | 112 | Raptors | 127 |
| November | 16, 2021 | Wolves | 101 | Raptors | 121 |
| November | 19, 2021 | Pistons | 103 | Raptors | 87 |
| November | 21, 2021 | Raptors | 104 | Lakers | 102 |
| November | 22, 2021 | Cavaliers | 109 | Raptors | 122 |
| November | 23, 2021 | Raptors | 120 | Mavericks | 89 |
| November | 25, 2021 | Hornets | 100 | Raptors | 111 |
| November | 27, 2021 | Nuggets | 91 | Raptors | 124 |
| November | 29, 2021 | Hornets | 102 | Raptors | 118 |
| December | 2, 2021 | Raptors | 111 | Bulls | 98 |
| December | 3, 2021 | Raptors | 127 | Nuggets | 87 |
| December | 5, 2021 | Bucks | 117 | Raptors | 110 |
| December | 6, 2021 | Knicks | 100 | Raptors | 123 |
| December | 8, 2021 | Trailblazers | 82 | Raptors | 112 |
| December | 9, 2021 | Raptors | 109 | Thunder | 96 |
| December | 10, 2021 | Raptors | 109 | Pistons | 91 |
| December | 13, 2021 | Raptors | 92 | Pelicans | 108 |
| December | 16, 2021 | Raptors | 141 | Magic | 104 |
| December | 17, 2021 | Raptors | 118 | Pacers | 93 |
| December | 20, 2021 | Raptors | 125 | Jazz | 108 |
| December | 22, 2021 | Raptors | 125 | Celtics | 105 |
| December | 23, 2021 | Raptors | 111 | Wizards | 119 |
| December | 28, 2021 | Raptors | 83 | Heat | 85 |
| December | 30, 2021 | 76ers | 69 | Raptors | 106 |
| January | 1, 2022 | Jazz | 102 | Raptors | 127 |
| January | 4, 2022 | Lakers | 96 | Raptors | 126 |
| January | 5, 2022 | Nets | 95 | Raptors | 129 |
| January | 8, 2022 | Raptors | 120 | Clippers | 101 |
| January | 10, 2022 | Pacers | 93 | Raptors | 130 |
| January | 12, 2022 | Wizards | 81 | Raptors | 119 |
| January | 13, 2022 | Warriors | 125 | Raptors | 113 |
| January | 15, 2022 | Wizards | 83 | Raptors | 130 |
| January | 17, 2022 | Raptors | 97 | Knicks | 100 |
| January | 18, 2022 | Raptors | 128 | Grizzlies | 120 |
| January | 21, 2022 | Raptors | 109 | Rockets | 92 |
| January | 23, 2022 | Pistons | 84 | Raptors | 74 |
| January | 26, 2022 | Raptors | 95 | 76ers | 77 |
| January | 27, 2022 | Heat | 109 | Raptors | 100 |
| January | 30, 2022 | Grizzlies | 101 | Raptors | 125 |
| February | 1, 2022 | Raptors | 113 | Kings | 118 |
| February | 2, 2022 | Raptors | 84 | Pistons | 70 |
| February | 4, 2022 | Nets | 117 | Raptors | 131 |
| February | 6, 2022 | Rockets | 112 | Raptors | 121 |
| February | 13, 2022 | Knicks | 80 | Raptors | 99 |
| February | 16, 2022 | Raptors | 100 | Hawks | 97 |
| February | 20, 2022 | Raptors | 103 | Cavaliers | 98 |
| February | 22, 2022 | Hawks | 104 | Raptors | 107 |
| February | 23, 2022 | Raptors | 106 | Cavaliers | 126 |
| February | 25, 2022 | Raptors | 116 | Pacers | 104 |
| February | 26, 2022 | Kings | 78 | Raptors | 129 |
| March | 1, 2022 | Raptors | 111 | Trailblazers | 82 |
| March | 4, 2022 | Spurs | 106 | Raptors | 113 |
| March | 7, 2022 | Raptors | 121 | Celtics | 97 |
| March | 9, 2022 | Pacers | 100 | Raptors | 118 |
| March | 11, 2022 | 76ers | 86 | Raptors | 116 |
| March | 15, 2022 | Raptors | 115 | Magic | 130 |
| March | 18, 2022 | Raptors | 118 | Hornets | 104 |
| March | 21, 2022 | Clippers | 120 | Raptors | 106 |
| March | 24, 2022 | Raptors | 96 | Spurs | 116 |
| March | 28, 2022 | Raptors | 112 | Bucks | 116 |
| March | 30, 2022 | Heat | 79 | Raptors | 94 |
| April | 2, 2022 | Suns | 120 | Raptors | 108 |
| April | 4, 2022 | Raptors | 102 | Hawks | 110 |
| April | 6, 2022 | Bulls | 94 | Raptors | 111 |
| April | 9, 2022 | Celtics | 101 | Raptors | 114 |
| April | 11, 2022 | Raptors | 103 | Bucks | 115 |
| April | 12, 2022 | Raptors | 102 | 76ers | 78 |
| April | 14, 2022 | Raptors | 114 | Bulls | 121 |
| April | 17, 2022 | Raptors | 100 | Suns | 81 |
| April | 18, 2022 | Magic | 107 | Raptors | 133 |
| April | 21, 2022 | Raptors | 122 | Wolves | 128 |
| April | 24, 2022 | Raptors | 129 | Wizards | 112 |
| April | 25, 2022 | Raptors | 122 | Knicks | 113 |
| April | 27, 2022 | Cavaliers | 95 | Raptors | 120 |
| April | 30, 2022 | Raptors | 101 | Heat | 82 |
| May | 1, 2022 | Raptors | 89 | Nets | 70 |
| Post | 1, 2022 | Cavaliers | 101 | Raptors | 111 |
| Post | 2, 2022 | Cavaliers | 115 | Raptors | 121 |
| Post | 3, 2022 | Raptors | 109 | Cavaliers | 125 |
| Post | 4, 2022 | Raptors | 108 | Cavaliers | 110 |
| Post | 5, 2022 | Cavaliers | 119 | Raptors | 141 |
| Post | 6, 2022 | Raptors | 110 | Cavaliers | 113 |
| Post | 7, 2022 | Cavaliers | 112 | Raptors | 124 |
| Post | 8, 2022 | Heat | 94 | Raptors | 119 |
| Post | 9, 2022 | Heat | 73 | Raptors | 120 |
| Post | 10, 2022 | Raptors | 101 | Heat | 103 |
| Post | 11, 2022 | Raptors | 89 | Heat | 81 |
| Post | 12, 2022 | Heat | 71 | Raptors | 92 |
| Post | 13, 2022 | Raptors | | Heat | |
| Post | 14, 2022 | Heat | | Raptors | |
| Post | 15, 2022 | Raptors | 100 | Bucks | 112 |
| Post | 16, 2022 | Raptors | 84 | Bucks | 106 |
| Post | 17, 2022 | Bucks | 101 | Raptors | 122 |
| Post | 18, 2022 | Bucks | 109 | Raptors | 119 |
| Post | 19, 2022 | Raptors | 116 | Bucks | 124 |
| Post | 20, 2022 | Bucks | 115 | Raptors | 103 |
| Post | 21, 2022 | Raptors | | Bucks | |