| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Jazz | 100 | Pelicans | 114 |
| November | 5, 2021 | Spurs | 103 | Pelicans | 109 |
| November | 6, 2021 | Pelicans | 99 | Rockets | 112 |
| November | 9, 2021 | Pacers | 106 | Pelicans | 116 |
| November | 10, 2021 | Kings | 120 | Pelicans | 122 |
| November | 13, 2021 | Pelicans | 87 | Raptors | 93 |
| November | 15, 2021 | Pelicans | 87 | Pistons | 88 |
| November | 18, 2021 | Pelicans | 78 | Heat | 83 |
| November | 20, 2021 | Mavericks | 88 | Pelicans | 101 |
| November | 22, 2021 | Pelicans | 109 | Nuggets | 104 |
| November | 23, 2021 | Wizards | 79 | Pelicans | 84 |
| November | 26, 2021 | Pelicans | 93 | Clippers | 107 |
| November | 29, 2021 | Bulls | 83 | Pelicans | 94 |
| November | 30, 2021 | Rockets | 83 | Pelicans | 85 |
| December | 2, 2021 | Pelicans | 92 | 76ers | 86 |
| December | 4, 2021 | Pelicans | 79 | Knicks | 99 |
| December | 5, 2021 | Pelicans | 107 | Wizards | 88 |
| December | 8, 2021 | Pelicans | 100 | Bucks | 114 |
| December | 10, 2021 | Pelicans | 98 | Wolves | 111 |
| December | 11, 2021 | Knicks | 83 | Pelicans | 94 |
| December | 13, 2021 | Raptors | 92 | Pelicans | 108 |
| December | 16, 2021 | Pelicans | 95 | Warriors | 122 |
| December | 19, 2021 | Heat | 101 | Pelicans | 99 |
| December | 20, 2021 | Thunder | 112 | Pelicans | 105 |
| December | 23, 2021 | Pelicans | 79 | Trailblazers | 100 |
| December | 26, 2021 | Cavaliers | 122 | Pelicans | 116 |
| December | 28, 2021 | Pelicans | 103 | Lakers | 127 |
| December | 30, 2021 | Nuggets | 100 | Pelicans | 110 |
| December | 31, 2021 | Pelicans | 93 | Suns | 108 |
| January | 3, 2022 | Hawks | 97 | Pelicans | 84 |
| January | 5, 2022 | 76ers | 81 | Pelicans | 85 |
| January | 7, 2022 | Pelicans | 91 | Grizzlies | 94 |
| January | 8, 2022 | Pelicans | 99 | Wolves | 112 |
| January | 10, 2022 | Thunder | 87 | Pelicans | 107 |
| January | 13, 2022 | Pelicans | 109 | Clippers | 100 |
| January | 15, 2022 | Hornets | 111 | Pelicans | 107 |
| January | 17, 2022 | Pelicans | 77 | Nets | 96 |
| January | 19, 2022 | Pelicans | 120 | Magic | 101 |
| January | 20, 2022 | Pelicans | 103 | Hornets | 88 |
| January | 22, 2022 | Pelicans | 116 | Celtics | 76 |
| January | 25, 2022 | Pelicans | 116 | Pacers | 139 |
| January | 26, 2022 | Pelicans | 108 | Cavaliers | 124 |
| January | 28, 2022 | Pelicans | 83 | Jazz | 85 |
| January | 29, 2022 | Pistons | 90 | Pelicans | 100 |
| January | 31, 2022 | Pelicans | 97 | Mavericks | 89 |
| February | 2, 2022 | Suns | 100 | Pelicans | 93 |
| February | 5, 2022 | Celtics | 85 | Pelicans | 118 |
| February | 6, 2022 | Jazz | 110 | Pelicans | 79 |
| February | 13, 2022 | Pelicans | 100 | Suns | 104 |
| February | 16, 2022 | Warriors | 100 | Pelicans | 113 |
| February | 17, 2022 | Grizzlies | 86 | Pelicans | 92 |
| February | 19, 2022 | Pelicans | 93 | Spurs | 118 |
| February | 20, 2022 | Trailblazers | 80 | Pelicans | 95 |
| February | 22, 2022 | Lakers | 112 | Pelicans | 102 |
| February | 24, 2022 | Pelicans | 113 | Kings | 109 |
| February | 27, 2022 | Pelicans | 85 | Hawks | 104 |
| March | 1, 2022 | Pelicans | 92 | Bulls | 87 |
| March | 4, 2022 | Wolves | 110 | Pelicans | 102 |
| March | 7, 2022 | Warriors | 127 | Pelicans | 131 |
| March | 9, 2022 | Pelicans | 130 | Lakers | 137 |
| March | 12, 2022 | Bucks | 117 | Pelicans | 94 |
| March | 15, 2022 | Nuggets | 83 | Pelicans | 104 |
| March | 16, 2022 | Nets | 111 | Pelicans | 114 |
| March | 19, 2022 | Pelicans | 96 | Grizzlies | 103 |
| March | 21, 2022 | Pelicans | 93 | Thunder | 121 |
| March | 24, 2022 | Trailblazers | 79 | Pelicans | 98 |
| March | 26, 2022 | Magic | 114 | Pelicans | 121 |
| March | 29, 2022 | Pelicans | 104 | Spurs | 134 |
| April | 1, 2022 | Rockets | 117 | Pelicans | 88 |
| April | 4, 2022 | Pelicans | 76 | Jazz | 87 |
| April | 6, 2022 | Suns | 98 | Pelicans | 103 |
| April | 8, 2022 | Grizzlies | 109 | Pelicans | 112 |
| April | 11, 2022 | Pelicans | 98 | Nuggets | 106 |
| April | 14, 2022 | Pelicans | 89 | Thunder | 123 |
| April | 17, 2022 | Wolves | 107 | Pelicans | 114 |
| April | 19, 2022 | Mavericks | 86 | Pelicans | 91 |
| April | 22, 2022 | Pelicans | 92 | Rockets | 98 |
| April | 25, 2022 | Lakers | 126 | Pelicans | 150 |
| April | 26, 2022 | Spurs | 109 | Pelicans | 102 |
| April | 29, 2022 | Pelicans | 111 | Kings | 115 |
| April | 30, 2022 | Clippers | 110 | Pelicans | 103 |
| May | 1, 2022 | Pelicans | 97 | Mavericks | 115 |
| Post | 1, 2022 | Pelicans | 89 | Warriors | 113 |
| Post | 2, 2022 | Pelicans | 105 | Warriors | 116 |
| Post | 3, 2022 | Warriors | 97 | Pelicans | 112 |
| Post | 4, 2022 | Warriors | 111 | Pelicans | 90 |
| Post | 5, 2022 | Pelicans | 102 | Warriors | 114 |
| Post | 6, 2022 | Warriors | | Pelicans | |
| Post | 7, 2022 | Pelicans | | Warriors | |