| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Pacers | 122 | Warriors | 123 |
| November | 5, 2021 | Pacers | 125 | Magic | 118 |
| November | 7, 2021 | Pacers | 114 | Spurs | 116 |
| November | 9, 2021 | Pacers | 106 | Pelicans | 116 |
| November | 10, 2021 | 76ers | 68 | Pacers | 113 |
| November | 13, 2021 | Pacers | 112 | Rockets | 103 |
| November | 14, 2021 | Pacers | 137 | Nuggets | 111 |
| November | 16, 2021 | Pacers | 118 | Kings | 127 |
| November | 19, 2021 | Nets | 94 | Pacers | 126 |
| November | 21, 2021 | Celtics | 127 | Pacers | 122 |
| November | 22, 2021 | Bulls | 103 | Pacers | 109 |
| November | 25, 2021 | Magic | 124 | Pacers | 150 |
| November | 27, 2021 | Heat | 74 | Pacers | 105 |
| November | 29, 2021 | Pacers | 121 | Wolves | 113 |
| November | 30, 2021 | Trailblazers | 84 | Pacers | 116 |
| December | 3, 2021 | Pacers | 120 | Hornets | 102 |
| December | 5, 2021 | Pistons | 98 | Pacers | 124 |
| December | 8, 2021 | 76ers | 73 | Pacers | 119 |
| December | 11, 2021 | Warriors | 112 | Pacers | 102 |
| December | 12, 2021 | Jazz | 127 | Pacers | 109 |
| December | 14, 2021 | Pacers | 96 | Wizards | 136 |
| December | 15, 2021 | Pacers | 115 | Lakers | 103 |
| December | 17, 2021 | Raptors | 118 | Pacers | 93 |
| December | 20, 2021 | Bucks | 113 | Pacers | 126 |
| December | 23, 2021 | Hornets | 116 | Pacers | 107 |
| December | 26, 2021 | Pacers | 119 | Pistons | 113 |
| December | 28, 2021 | Pacers | 102 | Cavaliers | 109 |
| December | 29, 2021 | Pacers | 109 | Hawks | 99 |
| December | 31, 2021 | Rockets | 121 | Pacers | 101 |
| January | 2, 2022 | Pacers | 123 | Mavericks | 101 |
| January | 4, 2022 | Pacers | 121 | Bucks | 110 |
| January | 5, 2022 | Knicks | 98 | Pacers | 129 |
| January | 8, 2022 | Suns | 92 | Pacers | 120 |
| January | 10, 2022 | Pacers | 93 | Raptors | 130 |
| January | 13, 2022 | Pacers | 114 | Heat | 105 |
| January | 16, 2022 | Pacers | 115 | Thunder | 118 |
| January | 18, 2022 | Kings | 108 | Pacers | 109 |
| January | 20, 2022 | Pacers | 122 | Heat | 110 |
| January | 23, 2022 | Wizards | 112 | Pacers | 115 |
| January | 25, 2022 | Pelicans | 116 | Pacers | 139 |
| January | 26, 2022 | Hawks | 109 | Pacers | 114 |
| January | 28, 2022 | Bulls | 98 | Pacers | 133 |
| January | 30, 2022 | Thunder | 106 | Pacers | 116 |
| January | 31, 2022 | Pacers | 116 | Bucks | 140 |
| February | 2, 2022 | Pacers | 133 | Celtics | 87 |
| February | 4, 2022 | Hawks | 91 | Pacers | 109 |
| February | 6, 2022 | Pacers | 99 | Suns | 130 |
| February | 7, 2022 | Knicks | 116 | Pacers | 124 |
| February | 13, 2022 | Pacers | 114 | 76ers | 98 |
| February | 16, 2022 | Pacers | 104 | Bulls | 114 |
| February | 17, 2022 | Pacers | 124 | Trailblazers | 101 |
| February | 19, 2022 | Pacers | 113 | Nets | 78 |
| February | 22, 2022 | Wolves | 113 | Pacers | 126 |
| February | 23, 2022 | Pacers | 104 | 76ers | 87 |
| February | 25, 2022 | Raptors | 116 | Pacers | 104 |
| February | 27, 2022 | Pacers | 124 | Magic | 139 |
| March | 2, 2022 | Hornets | 97 | Pacers | 117 |
| March | 5, 2022 | Pacers | 116 | Wizards | 113 |
| March | 6, 2022 | Clippers | 106 | Pacers | 108 |
| March | 9, 2022 | Pacers | 100 | Raptors | 118 |
| March | 12, 2022 | Lakers | 126 | Pacers | 120 |
| March | 14, 2022 | Pacers | 65 | Jazz | 80 |
| March | 18, 2022 | Bucks | 105 | Pacers | 85 |
| March | 20, 2022 | Pacers | 89 | Knicks | 103 |
| March | 23, 2022 | Nuggets | 92 | Pacers | 109 |
| March | 24, 2022 | Mavericks | 106 | Pacers | 120 |
| March | 27, 2022 | Pacers | 121 | Celtics | 92 |
| March | 30, 2022 | Pacers | 117 | Cavaliers | 109 |
| March | 31, 2022 | Spurs | 126 | Pacers | 142 |
| April | 2, 2022 | Pacers | 117 | Bulls | 125 |
| April | 4, 2022 | Cavaliers | 112 | Pacers | 102 |
| April | 5, 2022 | Grizzlies | 114 | Pacers | 128 |
| April | 7, 2022 | Pacers | 122 | Nets | 79 |
| April | 10, 2022 | Pacers | 92 | Grizzlies | 112 |
| April | 13, 2022 | Pistons | 92 | Pacers | 144 |
| April | 16, 2022 | Pacers | 117 | Hawks | 122 |
| April | 17, 2022 | Nets | 92 | Pacers | 110 |
| April | 19, 2022 | Heat | 107 | Pacers | 110 |
| April | 22, 2022 | Pacers | 114 | Hornets | 117 |
| April | 24, 2022 | Celtics | 77 | Pacers | 105 |
| April | 28, 2022 | Pacers | 128 | Clippers | 116 |
| May | 1, 2022 | Wizards | 108 | Pacers | 122 |
| Post | 1, 2022 | Bulls | 105 | Pacers | 81 |
| Post | 2, 2022 | Bulls | 86 | Pacers | 68 |
| Post | 3, 2022 | Pacers | 99 | Bulls | 115 |
| Post | 4, 2022 | Pacers | 106 | Bulls | 82 |
| Post | 5, 2022 | Bulls | 110 | Pacers | 94 |
| Post | 6, 2022 | Pacers | | Bulls | |
| Post | 7, 2022 | Bulls | | Pacers | |