| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Rockets | 91 | Mavericks | 95 |
| November | 5, 2021 | Trailblazers | 81 | Mavericks | 100 |
| November | 7, 2021 | Mavericks | 105 | Raptors | 116 |
| November | 8, 2021 | Mavericks | 73 | Pistons | 81 |
| November | 10, 2021 | Mavericks | 103 | Bulls | 96 |
| November | 13, 2021 | Knicks | 84 | Mavericks | 92 |
| November | 15, 2021 | Mavericks | 116 | Nuggets | 107 |
| November | 18, 2021 | Jazz | 79 | Mavericks | 107 |
| November | 20, 2021 | Mavericks | 88 | Pelicans | 101 |
| November | 23, 2021 | Raptors | 120 | Mavericks | 89 |
| November | 25, 2021 | Mavericks | 111 | Grizzlies | 107 |
| November | 27, 2021 | 76ers | 63 | Mavericks | 99 |
| November | 29, 2021 | Mavericks | 103 | Magic | 68 |
| December | 1, 2021 | Mavericks | 110 | Nets | 105 |
| December | 3, 2021 | Mavericks | 91 | Heat | 70 |
| December | 4, 2021 | Mavericks | 123 | Lakers | 128 |
| December | 7, 2021 | Hornets | 94 | Mavericks | 98 |
| December | 9, 2021 | Mavericks | 106 | Warriors | 100 |
| December | 11, 2021 | Heat | 91 | Mavericks | 101 |
| December | 13, 2021 | Mavericks | 90 | Wolves | 114 |
| December | 15, 2021 | Mavericks | 107 | Celtics | 109 |
| December | 18, 2021 | Mavericks | 107 | Bucks | 111 |
| December | 20, 2021 | Suns | 121 | Mavericks | 131 |
| December | 21, 2021 | Spurs | 114 | Mavericks | 111 |
| December | 25, 2021 | Cavaliers | 121 | Mavericks | 107 |
| December | 26, 2021 | Grizzlies | 120 | Mavericks | 123 |
| December | 29, 2021 | Mavericks | 83 | Trailblazers | 81 |
| December | 31, 2021 | Mavericks | 107 | Thunder | 100 |
| January | 2, 2022 | Pacers | 123 | Mavericks | 101 |
| January | 4, 2022 | Mavericks | 116 | Kings | 102 |
| January | 6, 2022 | Nets | 91 | Mavericks | 88 |
| January | 9, 2022 | Mavericks | 99 | Hornets | 109 |
| January | 12, 2022 | Lakers | 109 | Mavericks | 119 |
| January | 14, 2022 | Nuggets | 90 | Mavericks | 116 |
| January | 16, 2022 | Mavericks | 91 | Jazz | 115 |
| January | 17, 2022 | Wizards | 103 | Mavericks | 117 |
| January | 20, 2022 | Mavericks | 114 | Rockets | 106 |
| January | 23, 2022 | Clippers | 99 | Mavericks | 114 |
| January | 25, 2022 | Thunder | 95 | Mavericks | 114 |
| January | 28, 2022 | Mavericks | 92 | Wolves | 116 |
| January | 31, 2022 | Pelicans | 97 | Mavericks | 89 |
| February | 4, 2022 | Mavericks | 91 | Cavaliers | 112 |
| February | 5, 2022 | Mavericks | 92 | 76ers | 79 |
| February | 7, 2022 | Mavericks | 96 | Trailblazers | 77 |
| February | 13, 2022 | Hawks | 95 | Mavericks | 88 |
| February | 16, 2022 | Kings | 90 | Mavericks | 109 |
| February | 17, 2022 | Mavericks | 91 | Suns | 105 |
| February | 19, 2022 | Rockets | 75 | Mavericks | 88 |
| February | 20, 2022 | Mavericks | 105 | Wizards | 94 |
| February | 22, 2022 | Mavericks | 98 | Warriors | 91 |
| February | 24, 2022 | Suns | 100 | Mavericks | 116 |
| February | 27, 2022 | Bulls | 80 | Mavericks | 85 |
| February | 28, 2022 | Mavericks | 88 | Nuggets | 78 |
| March | 2, 2022 | Pistons | 98 | Mavericks | 94 |
| March | 3, 2022 | Warriors | 111 | Mavericks | 103 |
| March | 6, 2022 | Mavericks | 121 | Kings | 126 |
| March | 8, 2022 | Mavericks | 116 | Jazz | 111 |
| March | 10, 2022 | Mavericks | 106 | Thunder | 123 |
| March | 12, 2022 | Celtics | 93 | Mavericks | 122 |
| March | 15, 2022 | Trailblazers | 60 | Mavericks | 86 |
| March | 18, 2022 | Mavericks | 116 | Clippers | 127 |
| March | 19, 2022 | Magic | 107 | Mavericks | 98 |
| March | 21, 2022 | Grizzlies | 106 | Mavericks | 89 |
| March | 24, 2022 | Mavericks | 106 | Pacers | 120 |
| March | 27, 2022 | Mavericks | 97 | Knicks | 95 |
| April | 1, 2022 | Warriors | 99 | Mavericks | 96 |
| April | 2, 2022 | Kings | 99 | Mavericks | 135 |
| April | 4, 2022 | Mavericks | 96 | Suns | 104 |
| April | 6, 2022 | Thunder | 92 | Mavericks | 119 |
| April | 7, 2022 | Lakers | 114 | Mavericks | 106 |
| April | 10, 2022 | Wolves | 104 | Mavericks | 115 |
| April | 12, 2022 | Mavericks | 108 | Rockets | 96 |
| April | 13, 2022 | Mavericks | 98 | Spurs | 114 |
| April | 15, 2022 | Nuggets | 90 | Mavericks | 115 |
| April | 17, 2022 | Clippers | 93 | Mavericks | 114 |
| April | 19, 2022 | Mavericks | 86 | Pelicans | 91 |
| April | 21, 2022 | Mavericks | 111 | Lakers | 95 |
| April | 23, 2022 | Bucks | 117 | Mavericks | 104 |
| April | 26, 2022 | Mavericks | 109 | Grizzlies | 132 |
| April | 28, 2022 | Mavericks | 100 | Hawks | 111 |
| April | 29, 2022 | Spurs | 134 | Mavericks | 104 |
| May | 1, 2022 | Pelicans | 97 | Mavericks | 115 |
| Post | 1, 2022 | Mavericks | 90 | Grizzlies | 91 |
| Post | 2, 2022 | Mavericks | 79 | Grizzlies | 119 |
| Post | 3, 2022 | Grizzlies | 113 | Mavericks | 83 |
| Post | 4, 2022 | Grizzlies | 114 | Mavericks | 79 |
| Post | 5, 2022 | Mavericks | | Grizzlies | |
| Post | 6, 2022 | Grizzlies | | Mavericks | |
| Post | 7, 2022 | Mavericks | | Grizzlies | |