| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Clippers | 82 | Lakers | 123 |
| November | 5, 2021 | Lakers | 110 | Jazz | 130 |
| November | 7, 2021 | Thunder | 101 | Lakers | 118 |
| November | 10, 2021 | Trailblazers | 117 | Lakers | 102 |
| November | 12, 2021 | Lakers | 103 | Knicks | 119 |
| November | 15, 2021 | Lakers | 101 | Nets | 102 |
| November | 17, 2021 | Nuggets | 130 | Lakers | 137 |
| November | 19, 2021 | Lakers | 85 | Spurs | 115 |
| November | 21, 2021 | Raptors | 104 | Lakers | 102 |
| November | 24, 2021 | Lakers | 130 | Warriors | 108 |
| November | 26, 2021 | Wolves | 96 | Lakers | 112 |
| November | 28, 2021 | Lakers | 114 | Celtics | 122 |
| November | 30, 2021 | Lakers | 128 | Wizards | 111 |
| December | 2, 2021 | Lakers | 129 | Kings | 132 |
| December | 4, 2021 | Mavericks | 123 | Lakers | 128 |
| December | 7, 2021 | Pistons | 89 | Lakers | 113 |
| December | 8, 2021 | Knicks | 88 | Lakers | 97 |
| December | 10, 2021 | Grizzlies | 86 | Lakers | 82 |
| December | 12, 2021 | Lakers | 115 | Suns | 125 |
| December | 15, 2021 | Pacers | 115 | Lakers | 103 |
| December | 17, 2021 | Magic | 125 | Lakers | 117 |
| December | 18, 2021 | Lakers | 103 | Jazz | 115 |
| December | 20, 2021 | Cavaliers | 115 | Lakers | 122 |
| December | 22, 2021 | Lakers | 119 | Thunder | 135 |
| December | 25, 2021 | Spurs | 113 | Lakers | 105 |
| December | 28, 2021 | Pelicans | 103 | Lakers | 127 |
| December | 30, 2021 | Lakers | 107 | Hornets | 113 |
| January | 1, 2022 | Lakers | 124 | Hawks | 119 |
| January | 4, 2022 | Lakers | 96 | Raptors | 126 |
| January | 6, 2022 | Rockets | 106 | Lakers | 116 |
| January | 8, 2022 | Lakers | 89 | Trailblazers | 98 |
| January | 10, 2022 | Heat | 116 | Lakers | 98 |
| January | 12, 2022 | Lakers | 109 | Mavericks | 119 |
| January | 16, 2022 | Lakers | 109 | Bulls | 115 |
| January | 19, 2022 | Lakers | 84 | 76ers | 101 |
| January | 20, 2022 | Lakers | 115 | Bucks | 123 |
| January | 21, 2022 | Hawks | 114 | Lakers | 110 |
| January | 24, 2022 | Spurs | 123 | Lakers | 87 |
| January | 27, 2022 | Lakers | 96 | Rockets | 135 |
| January | 28, 2022 | Kings | 134 | Lakers | 126 |
| January | 31, 2022 | Lakers | 98 | Grizzlies | 134 |
| February | 1, 2022 | Lakers | 106 | Nuggets | 115 |
| February | 4, 2022 | Lakers | 119 | Trailblazers | 109 |
| February | 5, 2022 | Lakers | 128 | Clippers | 118 |
| February | 7, 2022 | Hornets | 112 | Lakers | 113 |
| February | 14, 2022 | Suns | 116 | Lakers | 123 |
| February | 17, 2022 | Lakers | 106 | Cavaliers | 100 |
| February | 18, 2022 | Lakers | 98 | Pistons | 129 |
| February | 20, 2022 | Celtics | 114 | Lakers | 115 |
| February | 22, 2022 | Lakers | 112 | Pelicans | 102 |
| February | 24, 2022 | Warriors | 123 | Lakers | 98 |
| February | 26, 2022 | Lakers | 112 | Wolves | 123 |
| February | 28, 2022 | Wizards | 100 | Lakers | 142 |
| March | 2, 2022 | Lakers | 113 | Heat | 115 |
| March | 3, 2022 | Lakers | 127 | Magic | 124 |
| March | 6, 2022 | Trailblazers | 98 | Lakers | 119 |
| March | 7, 2022 | Lakers | 106 | Thunder | 118 |
| March | 9, 2022 | Pelicans | 130 | Lakers | 137 |
| March | 12, 2022 | Lakers | 126 | Pacers | 120 |
| March | 15, 2022 | Lakers | 90 | Spurs | 116 |
| March | 16, 2022 | Kings | 102 | Lakers | 114 |
| March | 19, 2022 | Lakers | 108 | Warriors | 122 |
| March | 22, 2022 | 76ers | 98 | Lakers | 119 |
| March | 24, 2022 | Suns | 113 | Lakers | 124 |
| March | 27, 2022 | Rockets | 108 | Lakers | 125 |
| March | 28, 2022 | Lakers | 120 | Nuggets | 103 |
| March | 30, 2022 | Jazz | 93 | Lakers | 128 |
| April | 1, 2022 | Lakers | 114 | Wolves | 141 |
| April | 2, 2022 | Lakers | 107 | Rockets | 105 |
| April | 4, 2022 | Thunder | 127 | Lakers | 117 |
| April | 7, 2022 | Lakers | 114 | Mavericks | 106 |
| April | 10, 2022 | Nets | 118 | Lakers | 103 |
| April | 13, 2022 | Lakers | 102 | Kings | 120 |
| April | 14, 2022 | Grizzlies | 125 | Lakers | 133 |
| April | 16, 2022 | Bucks | 120 | Lakers | 103 |
| April | 19, 2022 | Bulls | 123 | Lakers | 101 |
| April | 21, 2022 | Mavericks | 111 | Lakers | 95 |
| April | 24, 2022 | Lakers | 116 | Clippers | 121 |
| April | 25, 2022 | Lakers | 126 | Pelicans | 150 |
| April | 27, 2022 | Nuggets | 126 | Lakers | 119 |
| April | 28, 2022 | Warriors | 132 | Lakers | 128 |
| May | 1, 2022 | Wolves | 122 | Lakers | 127 |