| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Hornets | 93 | Knicks | 96 |
| November | 4, 2021 | Celtics | 119 | Hornets | 104 |
| November | 6, 2021 | Cavaliers | 110 | Hornets | 109 |
| November | 8, 2021 | Bucks | 109 | Hornets | 126 |
| November | 10, 2021 | Grizzlies | 98 | Hornets | 132 |
| November | 12, 2021 | Hornets | 102 | Wizards | 107 |
| November | 14, 2021 | Jazz | 117 | Hornets | 123 |
| November | 15, 2021 | Hawks | 93 | Hornets | 107 |
| November | 17, 2021 | Hornets | 124 | Celtics | 111 |
| November | 19, 2021 | 76ers | 89 | Hornets | 84 |
| November | 22, 2021 | Rockets | 109 | Hornets | 112 |
| November | 25, 2021 | Hornets | 100 | Raptors | 111 |
| November | 29, 2021 | Hornets | 102 | Raptors | 118 |
| November | 30, 2021 | Clippers | 101 | Hornets | 121 |
| December | 2, 2021 | Cavaliers | 115 | Hornets | 111 |
| December | 3, 2021 | Pacers | 120 | Hornets | 102 |
| December | 6, 2021 | Hornets | 99 | Thunder | 104 |
| December | 7, 2021 | Hornets | 94 | Mavericks | 98 |
| December | 9, 2021 | Hornets | 118 | Nuggets | 96 |
| December | 12, 2021 | Pistons | 81 | Hornets | 109 |
| December | 13, 2021 | Hornets | 113 | Magic | 107 |
| December | 15, 2021 | Heat | 97 | Hornets | 102 |
| December | 17, 2021 | Bulls | 95 | Hornets | 98 |
| December | 18, 2021 | Hornets | 125 | Kings | 111 |
| December | 21, 2021 | Hornets | 128 | Suns | 116 |
| December | 23, 2021 | Hornets | 116 | Pacers | 107 |
| December | 27, 2021 | Knicks | 91 | Hornets | 104 |
| December | 28, 2021 | Nets | 105 | Hornets | 111 |
| December | 30, 2021 | Lakers | 107 | Hornets | 113 |
| January | 1, 2022 | Hornets | 77 | 76ers | 94 |
| January | 4, 2022 | Wizards | 95 | Hornets | 114 |
| January | 7, 2022 | Hornets | 97 | Bucks | 144 |
| January | 9, 2022 | Mavericks | 99 | Hornets | 109 |
| January | 10, 2022 | Hornets | 83 | Pistons | 81 |
| January | 13, 2022 | Hornets | 113 | Wolves | 117 |
| January | 15, 2022 | Hornets | 111 | Pelicans | 107 |
| January | 18, 2022 | Hornets | 97 | Cavaliers | 93 |
| January | 20, 2022 | Pelicans | 103 | Hornets | 88 |
| January | 22, 2022 | Kings | 90 | Hornets | 96 |
| January | 23, 2022 | Trailblazers | 90 | Hornets | 84 |
| January | 25, 2022 | Hornets | 86 | Heat | 78 |
| January | 27, 2022 | Celtics | 95 | Hornets | 104 |
| January | 29, 2022 | Hornets | 93 | Rockets | 94 |
| January | 30, 2022 | Nuggets | 74 | Hornets | 98 |
| February | 1, 2022 | Hornets | 88 | Nets | 113 |
| February | 2, 2022 | Magic | 105 | Hornets | 116 |
| February | 5, 2022 | Hornets | 82 | Bulls | 88 |
| February | 7, 2022 | Hornets | 112 | Lakers | 113 |
| February | 13, 2022 | Hornets | 111 | Jazz | 97 |
| February | 16, 2022 | Hornets | 77 | Magic | 117 |
| February | 19, 2022 | Thunder | 93 | Hornets | 133 |
| February | 22, 2022 | Hornets | 88 | Clippers | 98 |
| February | 24, 2022 | Wolves | 97 | Hornets | 104 |
| February | 25, 2022 | Hawks | 88 | Hornets | 90 |
| February | 27, 2022 | Hornets | 96 | Heat | 86 |
| February | 28, 2022 | Hornets | 107 | Celtics | 101 |
| March | 2, 2022 | Hornets | 97 | Pacers | 117 |
| March | 4, 2022 | Hornets | 92 | Knicks | 80 |
| March | 6, 2022 | Magic | 96 | Hornets | 112 |
| March | 7, 2022 | Hornets | 89 | Grizzlies | 108 |
| March | 9, 2022 | Hornets | 84 | Cavaliers | 111 |
| March | 11, 2022 | Suns | 99 | Hornets | 108 |
| March | 13, 2022 | Hornets | 85 | Trailblazers | 77 |
| March | 17, 2022 | Knicks | 72 | Hornets | 106 |
| March | 18, 2022 | Raptors | 118 | Hornets | 104 |
| March | 21, 2022 | Hornets | 93 | Pistons | 84 |
| March | 24, 2022 | Hornets | 121 | Bucks | 120 |
| March | 27, 2022 | Spurs | 120 | Hornets | 121 |
| March | 30, 2022 | Warriors | 108 | Hornets | 113 |
| March | 31, 2022 | Hornets | 104 | Wizards | 108 |
| April | 3, 2022 | Hornets | 79 | Hawks | 97 |
| April | 5, 2022 | Wizards | 117 | Hornets | 100 |
| April | 7, 2022 | 76ers | 93 | Hornets | 86 |
| April | 10, 2022 | Hornets | 88 | Hawks | 85 |
| April | 13, 2022 | Hornets | 101 | Nets | 99 |
| April | 16, 2022 | Hornets | 114 | Warriors | 124 |
| April | 19, 2022 | Hornets | 115 | Spurs | 119 |
| April | 22, 2022 | Pacers | 114 | Hornets | 117 |
| April | 24, 2022 | Nets | 87 | Hornets | 89 |
| April | 27, 2022 | Pistons | 99 | Hornets | 110 |
| April | 28, 2022 | Bulls | 96 | Hornets | 90 |
| May | 1, 2022 | Bucks | 102 | Hornets | 121 |
| Post | 1, 2022 | Heat | 84 | Hornets | 74 |
| Post | 2, 2022 | Heat | 82 | Hornets | 88 |
| Post | 3, 2022 | Hornets | 81 | Heat | 92 |
| Post | 4, 2022 | Hornets | 85 | Heat | 78 |
| Post | 5, 2022 | Heat | 99 | Hornets | 80 |
| Post | 6, 2022 | Hornets | 96 | Heat | 109 |
| Post | 7, 2022 | Heat | | Hornets | |