| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Heat | 93 | Cavaliers | 108 |
| November | 3, 2021 | Heat | 94 | Bulls | 99 |
| November | 6, 2021 | Celtics | 91 | Heat | 101 |
| November | 7, 2021 | Heat | 97 | 76ers | 96 |
| November | 10, 2021 | Nets | 91 | Heat | 98 |
| November | 12, 2021 | Heat | 98 | Grizzlies | 110 |
| November | 14, 2021 | Heat | 98 | Suns | 88 |
| November | 18, 2021 | Pelicans | 78 | Heat | 83 |
| November | 20, 2021 | Hawks | 90 | Heat | 76 |
| November | 23, 2021 | Heat | 78 | Bucks | 109 |
| November | 24, 2021 | Knicks | 98 | Heat | 93 |
| November | 27, 2021 | Heat | 74 | Pacers | 105 |
| November | 30, 2021 | Warriors | 86 | Heat | 84 |
| December | 3, 2021 | Mavericks | 91 | Heat | 70 |
| December | 5, 2021 | Trailblazers | 87 | Heat | 102 |
| December | 8, 2021 | Wolves | 93 | Heat | 90 |
| December | 9, 2021 | Heat | 94 | Nets | 105 |
| December | 11, 2021 | Heat | 91 | Mavericks | 101 |
| December | 13, 2021 | Cavaliers | 87 | Heat | 90 |
| December | 15, 2021 | Heat | 97 | Hornets | 102 |
| December | 18, 2021 | Nuggets | 108 | Heat | 117 |
| December | 19, 2021 | Heat | 101 | Pelicans | 99 |
| December | 21, 2021 | Clippers | 89 | Heat | 106 |
| December | 23, 2021 | Heat | 102 | Rockets | 80 |
| December | 26, 2021 | Bulls | 112 | Heat | 82 |
| December | 28, 2021 | Raptors | 83 | Heat | 85 |
| December | 31, 2021 | Heat | 75 | Wizards | 99 |
| January | 2, 2022 | Nets | 89 | Heat | 101 |
| January | 3, 2022 | Heat | 87 | Knicks | 86 |
| January | 5, 2022 | Pistons | 83 | Heat | 89 |
| January | 8, 2022 | Magic | 103 | Heat | 102 |
| January | 10, 2022 | Heat | 116 | Lakers | 98 |
| January | 13, 2022 | Pacers | 114 | Heat | 105 |
| January | 15, 2022 | Heat | 98 | Thunder | 87 |
| January | 16, 2022 | Grizzlies | 95 | Heat | 106 |
| January | 18, 2022 | Heat | 99 | Wizards | 83 |
| January | 20, 2022 | Pacers | 122 | Heat | 110 |
| January | 22, 2022 | Heat | 79 | Magic | 75 |
| January | 25, 2022 | Hornets | 86 | Heat | 78 |
| January | 27, 2022 | Heat | 109 | Raptors | 100 |
| January | 31, 2022 | Heat | 94 | Kings | 117 |
| February | 2, 2022 | Bucks | 87 | Heat | 112 |
| February | 5, 2022 | Heat | 123 | Jazz | 93 |
| February | 6, 2022 | Cavaliers | 86 | Heat | 89 |
| February | 13, 2022 | Bulls | 92 | Heat | 94 |
| February | 15, 2022 | Heat | 98 | Clippers | 90 |
| February | 17, 2022 | Heat | 113 | Celtics | 95 |
| February | 19, 2022 | Heat | 97 | Hawks | 93 |
| February | 21, 2022 | Spurs | 101 | Heat | 91 |
| February | 22, 2022 | Heat | 83 | Pistons | 91 |
| February | 24, 2022 | Wizards | 92 | Heat | 87 |
| February | 25, 2022 | Heat | 94 | 76ers | 92 |
| February | 27, 2022 | Hornets | 96 | Heat | 86 |
| March | 2, 2022 | Lakers | 113 | Heat | 115 |
| March | 4, 2022 | Thunder | 78 | Heat | 115 |
| March | 6, 2022 | Rockets | 72 | Heat | 83 |
| March | 7, 2022 | Knicks | 93 | Heat | 99 |
| March | 10, 2022 | Kings | 96 | Heat | 105 |
| March | 12, 2022 | Heat | 89 | Trailblazers | 80 |
| March | 15, 2022 | Heat | 95 | Bulls | 97 |
| March | 18, 2022 | Jazz | 78 | Heat | 99 |
| March | 20, 2022 | Heat | 80 | Hawks | 87 |
| March | 21, 2022 | Magic | 91 | Heat | 97 |
| March | 24, 2022 | Heat | 90 | Celtics | 75 |
| March | 27, 2022 | Heat | 88 | Warriors | 84 |
| March | 30, 2022 | Heat | 79 | Raptors | 94 |
| April | 2, 2022 | Heat | 88 | Bucks | 100 |
| April | 4, 2022 | Heat | 107 | Spurs | 117 |
| April | 5, 2022 | 76ers | 95 | Heat | 80 |
| April | 7, 2022 | Heat | 117 | Nuggets | 86 |
| April | 9, 2022 | Heat | 95 | Wolves | 98 |
| April | 11, 2022 | Pistons | 82 | Heat | 93 |
| April | 12, 2022 | Wizards | 100 | Heat | 112 |
| April | 14, 2022 | Heat | 104 | Cavaliers | 99 |
| April | 16, 2022 | 76ers | 88 | Heat | 98 |
| April | 19, 2022 | Heat | 107 | Pacers | 110 |
| April | 21, 2022 | Heat | 75 | Pistons | 97 |
| April | 24, 2022 | Bucks | 100 | Heat | 91 |
| April | 26, 2022 | Suns | 89 | Heat | 103 |
| April | 28, 2022 | Heat | 113 | Magic | 118 |
| April | 30, 2022 | Raptors | 101 | Heat | 82 |
| May | 1, 2022 | Heat | 90 | Knicks | 105 |
| Post | 1, 2022 | Heat | 84 | Hornets | 74 |
| Post | 2, 2022 | Heat | 82 | Hornets | 88 |
| Post | 3, 2022 | Hornets | 81 | Heat | 92 |
| Post | 4, 2022 | Hornets | 85 | Heat | 78 |
| Post | 5, 2022 | Heat | 99 | Hornets | 80 |
| Post | 6, 2022 | Hornets | 96 | Heat | 109 |
| Post | 7, 2022 | Heat | | Hornets | |
| Post | 8, 2022 | Heat | 94 | Raptors | 119 |
| Post | 9, 2022 | Heat | 73 | Raptors | 120 |
| Post | 10, 2022 | Raptors | 101 | Heat | 103 |
| Post | 11, 2022 | Raptors | 89 | Heat | 81 |
| Post | 12, 2022 | Heat | 71 | Raptors | 92 |
| Post | 13, 2022 | Raptors | | Heat | |
| Post | 14, 2022 | Heat | | Raptors | |