| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Heat | 94 | Bulls | 99 |
| November | 4, 2021 | Bulls | 95 | Hawks | 86 |
| November | 6, 2021 | Bulls | 95 | Raptors | 116 |
| November | 8, 2021 | Bulls | 110 | Clippers | 125 |
| November | 10, 2021 | Mavericks | 103 | Bulls | 96 |
| November | 11, 2021 | Bucks | 108 | Bulls | 100 |
| November | 13, 2021 | Bulls | 114 | Warriors | 120 |
| November | 14, 2021 | Grizzlies | 82 | Bulls | 99 |
| November | 17, 2021 | Spurs | 100 | Bulls | 97 |
| November | 20, 2021 | Thunder | 76 | Bulls | 105 |
| November | 22, 2021 | Bulls | 103 | Pacers | 109 |
| November | 24, 2021 | Rockets | 87 | Bulls | 108 |
| November | 26, 2021 | Magic | 93 | Bulls | 97 |
| November | 28, 2021 | Bulls | 103 | Bucks | 120 |
| November | 29, 2021 | Bulls | 83 | Pelicans | 94 |
| December | 2, 2021 | Raptors | 111 | Bulls | 98 |
| December | 5, 2021 | Suns | 89 | Bulls | 106 |
| December | 6, 2021 | Bulls | 111 | Celtics | 107 |
| December | 8, 2021 | Bulls | 114 | Jazz | 103 |
| December | 10, 2021 | Bulls | 106 | Magic | 100 |
| December | 14, 2021 | Hawks | 91 | Bulls | 99 |
| December | 17, 2021 | Bulls | 95 | Hornets | 98 |
| December | 19, 2021 | Pistons | 76 | Bulls | 84 |
| December | 21, 2021 | Bulls | 91 | Kings | 114 |
| December | 26, 2021 | Bulls | 112 | Heat | 82 |
| December | 27, 2021 | 76ers | 90 | Bulls | 95 |
| December | 30, 2021 | Bulls | 90 | Pistons | 79 |
| January | 1, 2022 | Magic | 116 | Bulls | 115 |
| January | 2, 2022 | Wizards | 101 | Bulls | 104 |
| January | 4, 2022 | Cavaliers | 125 | Bulls | 100 |
| January | 7, 2022 | Kings | 111 | Bulls | 129 |
| January | 9, 2022 | Bulls | 108 | Nets | 116 |
| January | 10, 2022 | Bulls | 104 | 76ers | 77 |
| January | 13, 2022 | Hawks | 94 | Bulls | 79 |
| January | 16, 2022 | Lakers | 109 | Bulls | 115 |
| January | 18, 2022 | Bucks | 123 | Bulls | 113 |
| January | 19, 2022 | Wolves | 98 | Bulls | 107 |
| January | 21, 2022 | Trailblazers | 80 | Bulls | 90 |
| January | 23, 2022 | Nuggets | 79 | Bulls | 111 |
| January | 25, 2022 | Wizards | 104 | Bulls | 92 |
| January | 28, 2022 | Bulls | 98 | Pacers | 133 |
| January | 30, 2022 | Bulls | 134 | Pistons | 84 |
| February | 2, 2022 | Bulls | 95 | Knicks | 76 |
| February | 5, 2022 | Hornets | 82 | Bulls | 88 |
| February | 13, 2022 | Bulls | 92 | Heat | 94 |
| February | 14, 2022 | Cavaliers | 94 | Bulls | 98 |
| February | 16, 2022 | Pacers | 104 | Bulls | 114 |
| February | 18, 2022 | Bulls | 96 | Wizards | 88 |
| February | 21, 2022 | Knicks | 73 | Bulls | 103 |
| February | 24, 2022 | Bulls | 106 | Grizzlies | 82 |
| February | 25, 2022 | Jazz | 77 | Bulls | 89 |
| February | 27, 2022 | Bulls | 80 | Mavericks | 85 |
| March | 1, 2022 | Pelicans | 92 | Bulls | 87 |
| March | 3, 2022 | Celtics | 108 | Bulls | 113 |
| March | 4, 2022 | Clippers | 103 | Bulls | 107 |
| March | 6, 2022 | Bulls | 78 | Hawks | 103 |
| March | 8, 2022 | Nets | 95 | Bulls | 106 |
| March | 9, 2022 | Bulls | 95 | Spurs | 109 |
| March | 11, 2022 | Bulls | 128 | Celtics | 97 |
| March | 14, 2022 | Bulls | 116 | Nuggets | 106 |
| March | 15, 2022 | Heat | 95 | Bulls | 97 |
| March | 18, 2022 | Pistons | 103 | Bulls | 92 |
| March | 20, 2022 | Bulls | 106 | 76ers | 68 |
| March | 23, 2022 | Bulls | 117 | Magic | 94 |
| March | 24, 2022 | Bulls | 95 | Knicks | 89 |
| March | 27, 2022 | Bulls | 90 | Trailblazers | 86 |
| March | 30, 2022 | Bulls | 95 | Wolves | 96 |
| March | 31, 2022 | Bulls | 103 | Suns | 114 |
| April | 2, 2022 | Pacers | 117 | Bulls | 125 |
| April | 4, 2022 | Bulls | 79 | Rockets | 78 |
| April | 6, 2022 | Bulls | 94 | Raptors | 111 |
| April | 9, 2022 | Warriors | 91 | Bulls | 120 |
| April | 10, 2022 | 76ers | 80 | Bulls | 101 |
| April | 11, 2022 | Bulls | 73 | Thunder | 121 |
| April | 14, 2022 | Raptors | 114 | Bulls | 121 |
| April | 16, 2022 | Bulls | 101 | Cavaliers | 97 |
| April | 17, 2022 | Bulls | 102 | Wizards | 121 |
| April | 19, 2022 | Bulls | 123 | Lakers | 101 |
| April | 23, 2022 | Knicks | 87 | Bulls | 91 |
| April | 25, 2022 | Bulls | 88 | Nets | 81 |
| April | 28, 2022 | Bulls | 96 | Hornets | 90 |
| May | 1, 2022 | Celtics | 109 | Bulls | 132 |
| Post | 1, 2022 | Bulls | 105 | Pacers | 81 |
| Post | 2, 2022 | Bulls | 86 | Pacers | 68 |
| Post | 3, 2022 | Pacers | 99 | Bulls | 115 |
| Post | 4, 2022 | Pacers | 106 | Bulls | 82 |
| Post | 5, 2022 | Bulls | 110 | Pacers | 94 |
| Post | 6, 2022 | Pacers | | Bulls | |
| Post | 7, 2022 | Bulls | | Pacers | |
| Post | 8, 2022 | Bulls | 102 | Bucks | 117 |
| Post | 9, 2022 | Bulls | 101 | Bucks | 115 |
| Post | 10, 2022 | Bucks | 109 | Bulls | 110 |
| Post | 11, 2022 | Bucks | 123 | Bulls | 112 |
| Post | 12, 2022 | Bulls | 99 | Bucks | 107 |
| Post | 13, 2022 | Bucks | | Bulls | |
| Post | 14, 2022 | Bulls | | Bucks | |