| month | day | visitor | score | home | score |
|---|
| November | 4, 2020 | Wolves | 104 | Spurs | 131 |
| November | 7, 2020 | Spurs | 145 | Trailblazers | 123 |
| November | 9, 2020 | Spurs | 129 | Lakers | 104 |
| November | 12, 2020 | Pacers | 117 | Spurs | 121 |
| November | 16, 2020 | Lakers | 102 | Spurs | 123 |
| November | 18, 2020 | Mavericks | 125 | Spurs | 118 |
| November | 20, 2020 | Spurs | 99 | Suns | 93 |
| November | 23, 2020 | Pelicans | 101 | Spurs | 100 |
| November | 24, 2020 | Magic | 122 | Spurs | 143 |
| November | 27, 2020 | Spurs | 118 | Heat | 90 |
| November | 30, 2020 | Rockets | 104 | Spurs | 112 |
| December | 2, 2020 | Spurs | 82 | Kings | 105 |
| December | 4, 2020 | Spurs | 136 | Suns | 103 |
| December | 5, 2020 | Spurs | 129 | Clippers | 117 |
| December | 8, 2020 | Warriors | 107 | Spurs | 120 |
| December | 9, 2020 | Spurs | 116 | Pelicans | 129 |
| December | 11, 2020 | Grizzlies | 112 | Spurs | 117 |
| December | 14, 2020 | Spurs | 126 | Pacers | 135 |
| December | 15, 2020 | Spurs | 127 | Bucks | 117 |
| December | 17, 2020 | Spurs | 114 | Bulls | 111 |
| December | 19, 2020 | Spurs | 93 | Wolves | 110 |
| December | 21, 2020 | Rockets | 101 | Spurs | 90 |
| December | 23, 2020 | Trailblazers | 131 | Spurs | 139 |
| December | 26, 2020 | Spurs | 119 | Jazz | 97 |
| December | 27, 2020 | Spurs | 135 | Lakers | 122 |
| December | 29, 2020 | Lakers | 98 | Spurs | 114 |
| December | 31, 2020 | Jazz | 100 | Spurs | 78 |
| January | 2, 2021 | Suns | 103 | Spurs | 109 |
| January | 4, 2021 | Clippers | 108 | Spurs | 94 |
| January | 6, 2021 | Bulls | 90 | Spurs | 106 |
| January | 8, 2021 | 76ers | 118 | Spurs | 133 |
| January | 10, 2021 | Spurs | 140 | Magic | 142 |
| January | 12, 2021 | Wolves | 116 | Spurs | 111 |
| January | 13, 2021 | Spurs | 108 | Rockets | 107 |
| January | 16, 2021 | Nuggets | 107 | Spurs | 105 |
| January | 18, 2021 | Spurs | 113 | Nuggets | 91 |
| January | 19, 2021 | Spurs | 105 | Clippers | 108 |
| January | 21, 2021 | Celtics | 135 | Spurs | 149 |
| January | 24, 2021 | Raptors | 118 | Spurs | 110 |
| January | 26, 2021 | Grizzlies | 133 | Spurs | 146 |
| January | 28, 2021 | Spurs | 132 | Pistons | 138 |
| January | 30, 2021 | Spurs | 140 | Grizzlies | 105 |
| January | 31, 2021 | Thunder | 100 | Spurs | 142 |
| February | 2, 2021 | Spurs | 140 | Thunder | 94 |
| February | 5, 2021 | Hornets | 105 | Spurs | 109 |
| February | 7, 2021 | Spurs | 101 | Mavericks | 122 |
| February | 14, 2021 | Spurs | 110 | Wolves | 127 |
| February | 16, 2021 | Clippers | 93 | Spurs | 101 |
| February | 19, 2021 | Spurs | 121 | 76ers | 138 |
| February | 22, 2021 | Spurs | 100 | Pelicans | 87 |
| February | 23, 2021 | Wizards | 88 | Spurs | 106 |
| February | 25, 2021 | Suns | 106 | Spurs | 124 |
| February | 27, 2021 | Nets | 110 | Spurs | 114 |
| March | 2, 2021 | Pelicans | 91 | Spurs | 104 |
| March | 4, 2021 | Spurs | 86 | Kings | 111 |
| March | 6, 2021 | Spurs | 102 | Warriors | 122 |
| March | 7, 2021 | Spurs | 113 | Trailblazers | 125 |
| March | 9, 2021 | Spurs | 97 | Jazz | 85 |
| March | 12, 2021 | Spurs | 156 | Grizzlies | 112 |
| March | 16, 2021 | Spurs | 88 | Raptors | 123 |
| March | 18, 2021 | Spurs | 104 | Knicks | 98 |
| March | 19, 2021 | Spurs | 134 | Nets | 104 |
| March | 21, 2021 | Pistons | 107 | Spurs | 120 |
| March | 24, 2021 | Thunder | 115 | Spurs | 132 |
| March | 26, 2021 | Nuggets | 68 | Spurs | 103 |
| March | 28, 2021 | Spurs | 125 | Hawks | 127 |
| April | 1, 2021 | Bucks | 130 | Spurs | 127 |
| April | 3, 2021 | Spurs | 130 | Mavericks | 127 |
| April | 6, 2021 | Knicks | 82 | Spurs | 120 |
| April | 7, 2021 | Trailblazers | 99 | Spurs | 144 |
| April | 9, 2021 | Warriors | 118 | Spurs | 110 |
| April | 11, 2021 | Heat | 77 | Spurs | 116 |
| April | 13, 2021 | Spurs | 116 | Rockets | 96 |
| April | 15, 2021 | Spurs | 125 | Celtics | 100 |
| April | 17, 2021 | Spurs | 93 | Hornets | 118 |
| April | 19, 2021 | Cavaliers | 98 | Spurs | 121 |
| April | 22, 2021 | Kings | 105 | Spurs | 121 |
| April | 24, 2021 | Hawks | 109 | Spurs | 134 |
| April | 25, 2021 | Spurs | 130 | Nuggets | 105 |
| April | 27, 2021 | Spurs | 129 | Wizards | 101 |
| April | 29, 2021 | Spurs | 124 | Cavaliers | 115 |
| May | 1, 2021 | Mavericks | 113 | Spurs | 142 |
| Post | 1, 2021 | Pelicans | 103 | Spurs | 110 |
| Post | 2, 2021 | Pelicans | 101 | Spurs | 98 |
| Post | 3, 2021 | Spurs | 96 | Pelicans | 99 |
| Post | 4, 2021 | Spurs | 120 | Pelicans | 93 |
| Post | 5, 2021 | Pelicans | 93 | Spurs | 122 |
| Post | 6, 2021 | Spurs | 109 | Pelicans | 116 |
| Post | 7, 2021 | Pelicans | 123 | Spurs | 125 |
| Post | 8, 2021 | Jazz | 125 | Spurs | 120 |
| Post | 9, 2021 | Jazz | 104 | Spurs | 121 |
| Post | 10, 2021 | Spurs | 113 | Jazz | 115 |
| Post | 11, 2021 | Spurs | 121 | Jazz | 95 |
| Post | 12, 2021 | Jazz | 113 | Spurs | 104 |
| Post | 13, 2021 | Spurs | 131 | Jazz | 134 |
| Post | 14, 2021 | Jazz | | Spurs | |