| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Nets | 101 | Pistons | 105 |
| November | 7, 2020 | Pistons | 112 | Bulls | 134 |
| November | 10, 2020 | 76ers | 89 | Pistons | 121 |
| November | 13, 2020 | Cavaliers | 113 | Pistons | 106 |
| November | 15, 2020 | Celtics | 95 | Pistons | 128 |
| November | 19, 2020 | Pistons | 122 | Celtics | 104 |
| November | 20, 2020 | Pistons | 129 | Nets | 104 |
| November | 23, 2020 | Pistons | 116 | 76ers | 103 |
| November | 25, 2020 | Heat | 77 | Pistons | 116 |
| November | 27, 2020 | Pistons | 108 | Magic | 118 |
| November | 29, 2020 | Pistons | 105 | Hawks | 106 |
| December | 1, 2020 | Hornets | 90 | Pistons | 101 |
| December | 4, 2020 | Pistons | 90 | Raptors | 113 |
| December | 9, 2020 | Cavaliers | 110 | Pistons | 115 |
| December | 11, 2020 | Pistons | 112 | Rockets | 102 |
| December | 13, 2020 | Rockets | 97 | Pistons | 106 |
| December | 16, 2020 | Suns | 103 | Pistons | 128 |
| December | 18, 2020 | Knicks | 99 | Pistons | 102 |
| December | 21, 2020 | Bulls | 90 | Pistons | 127 |
| December | 22, 2020 | Warriors | 120 | Pistons | 106 |
| December | 25, 2020 | Thunder | 86 | Pistons | 115 |
| December | 27, 2020 | Pistons | 105 | Bucks | 124 |
| December | 29, 2020 | 76ers | 101 | Pistons | 109 |
| December | 31, 2020 | Pelicans | 100 | Pistons | 117 |
| January | 1, 2021 | Pistons | 118 | 76ers | 135 |
| January | 3, 2021 | Pistons | 103 | Hornets | 110 |
| January | 6, 2021 | Celtics | 100 | Pistons | 122 |
| January | 8, 2021 | Bucks | 123 | Pistons | 125 |
| January | 11, 2021 | Pistons | 113 | Wolves | 90 |
| January | 12, 2021 | Pistons | 107 | Hornets | 105 |
| January | 14, 2021 | Hawks | 89 | Pistons | 124 |
| January | 16, 2021 | Wizards | 85 | Pistons | 109 |
| January | 18, 2021 | Pistons | 108 | Pacers | 100 |
| January | 20, 2021 | Pistons | 138 | Magic | 109 |
| January | 22, 2021 | Pistons | 133 | Bucks | 129 |
| January | 23, 2021 | Pistons | 107 | Grizzlies | 124 |
| January | 26, 2021 | Jazz | 100 | Pistons | 102 |
| January | 28, 2021 | Spurs | 132 | Pistons | 138 |
| January | 30, 2021 | Pistons | 106 | Lakers | 95 |
| January | 31, 2021 | Pistons | 113 | Kings | 106 |
| February | 2, 2021 | Pistons | 108 | Clippers | 119 |
| February | 5, 2021 | Pistons | 105 | Jazz | 123 |
| February | 7, 2021 | Magic | 104 | Pistons | 118 |
| February | 14, 2021 | Heat | 92 | Pistons | 95 |
| February | 15, 2021 | Kings | 113 | Pistons | 109 |
| February | 17, 2021 | Pistons | 106 | Wizards | 98 |
| February | 19, 2021 | Pistons | 102 | Pelicans | 121 |
| February | 21, 2021 | Pistons | 136 | Mavericks | 137 |
| February | 25, 2021 | Bucks | 106 | Pistons | 98 |
| February | 27, 2021 | Mavericks | 119 | Pistons | 122 |
| March | 1, 2021 | Clippers | 95 | Pistons | 128 |
| March | 4, 2021 | Nuggets | 108 | Pistons | 124 |
| March | 5, 2021 | Pistons | 80 | Knicks | 100 |
| March | 8, 2021 | Knicks | 82 | Pistons | 111 |
| March | 11, 2021 | Wizards | 87 | Pistons | 107 |
| March | 13, 2021 | Pistons | 122 | Celtics | 115 |
| March | 16, 2021 | Pistons | 106 | Hawks | 114 |
| March | 17, 2021 | Pistons | 99 | Heat | 77 |
| March | 19, 2021 | Pacers | 121 | Pistons | 112 |
| March | 21, 2021 | Pistons | 107 | Spurs | 120 |
| March | 24, 2021 | Pistons | 127 | Cavaliers | 91 |
| March | 25, 2021 | Raptors | 125 | Pistons | 103 |
| March | 28, 2021 | Wolves | 87 | Pistons | 97 |
| March | 30, 2021 | Pistons | 105 | Bulls | 110 |
| April | 1, 2021 | Bulls | 100 | Pistons | 108 |
| April | 2, 2021 | Pistons | 112 | Nets | 111 |
| April | 4, 2021 | Pistons | 88 | Heat | 103 |
| April | 6, 2021 | Lakers | 114 | Pistons | 115 |
| April | 8, 2021 | Raptors | 113 | Pistons | 126 |
| April | 9, 2021 | Pistons | 121 | Cavaliers | 104 |
| April | 12, 2021 | Pistons | 98 | Suns | 103 |
| April | 14, 2021 | Pistons | 106 | Trailblazers | 100 |
| April | 15, 2021 | Pistons | 97 | Warriors | 104 |
| April | 17, 2021 | Pistons | 121 | Nuggets | 124 |
| April | 19, 2021 | Magic | 103 | Pistons | 106 |
| April | 21, 2021 | Trailblazers | 93 | Pistons | 117 |
| April | 23, 2021 | Pistons | 102 | Pacers | 134 |
| April | 25, 2021 | Pacers | 110 | Pistons | 131 |
| April | 27, 2021 | Pistons | 128 | Thunder | 118 |
| April | 29, 2021 | Hornets | 71 | Pistons | 110 |
| April | 30, 2021 | Grizzlies | 93 | Pistons | 137 |
| May | 1, 2021 | Pistons | 86 | Knicks | 93 |
| Post | 1, 2021 | Bulls | 81 | Pistons | 113 |
| Post | 2, 2021 | Bulls | 87 | Pistons | 119 |
| Post | 3, 2021 | Pistons | 129 | Bulls | 113 |
| Post | 4, 2021 | Pistons | 113 | Bulls | 102 |
| Post | 5, 2021 | Bulls | | Pistons | |
| Post | 6, 2021 | Pistons | | Bulls | |
| Post | 7, 2021 | Bulls | | Pistons | |
| Post | 8, 2021 | Hornets | 80 | Pistons | 92 |
| Post | 9, 2021 | Hornets | 93 | Pistons | 110 |
| Post | 10, 2021 | Pistons | 99 | Hornets | 84 |
| Post | 11, 2021 | Pistons | 107 | Hornets | 93 |
| Post | 12, 2021 | Hornets | | Pistons | |
| Post | 13, 2021 | Pistons | | Hornets | |
| Post | 14, 2021 | Hornets | | Pistons | |
| Post | 15, 2021 | Pistons | 97 | Pacers | 99 |
| Post | 16, 2021 | Pistons | 99 | Pacers | 105 |
| Post | 17, 2021 | Pacers | 98 | Pistons | 119 |
| Post | 18, 2021 | Pacers | 103 | Pistons | 107 |
| Post | 19, 2021 | Pistons | 111 | Pacers | 122 |
| Post | 20, 2021 | Pacers | 123 | Pistons | 108 |
| Post | 21, 2021 | Pistons | | Pacers | |