| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Hawks | 98 | Knicks | 85 |
| November | 6, 2020 | Knicks | 98 | Nets | 94 |
| November | 7, 2020 | Celtics | 83 | Knicks | 95 |
| November | 9, 2020 | Knicks | 88 | Bucks | 97 |
| November | 11, 2020 | Knicks | 81 | Heat | 104 |
| November | 14, 2020 | Warriors | 88 | Knicks | 100 |
| November | 18, 2020 | Nets | 87 | Knicks | 85 |
| November | 20, 2020 | Pacers | 113 | Knicks | 128 |
| November | 22, 2020 | Knicks | 117 | Mavericks | 134 |
| November | 24, 2020 | Knicks | 79 | Wizards | 87 |
| November | 25, 2020 | Bulls | 114 | Knicks | 105 |
| November | 27, 2020 | Knicks | 88 | Hawks | 96 |
| November | 30, 2020 | Knicks | 89 | Raptors | 112 |
| December | 1, 2020 | Magic | 128 | Knicks | 116 |
| December | 4, 2020 | Knicks | 91 | Thunder | 100 |
| December | 6, 2020 | Knicks | 105 | Pelicans | 90 |
| December | 8, 2020 | Knicks | 93 | Magic | 102 |
| December | 10, 2020 | Trailblazers | 127 | Knicks | 138 |
| December | 12, 2020 | Knicks | 132 | Celtics | 112 |
| December | 13, 2020 | Pelicans | 97 | Knicks | 92 |
| December | 16, 2020 | Knicks | 95 | Grizzlies | 114 |
| December | 18, 2020 | Knicks | 99 | Pistons | 102 |
| December | 19, 2020 | Knicks | 121 | 76ers | 98 |
| December | 22, 2020 | Bucks | 120 | Knicks | 102 |
| December | 25, 2020 | Wizards | 89 | Knicks | 112 |
| December | 28, 2020 | Knicks | 115 | Celtics | 124 |
| December | 30, 2020 | Nets | 101 | Knicks | 129 |
| December | 31, 2020 | Hornets | 82 | Knicks | 97 |
| January | 3, 2021 | Knicks | 94 | Cavaliers | 92 |
| January | 5, 2021 | Knicks | 97 | Hornets | 103 |
| January | 7, 2021 | Knicks | 98 | Pacers | 137 |
| January | 8, 2021 | Suns | 107 | Knicks | 101 |
| January | 10, 2021 | Knicks | 122 | 76ers | 96 |
| January | 12, 2021 | Hawks | 92 | Knicks | 102 |
| January | 15, 2021 | Bucks | 88 | Knicks | 98 |
| January | 17, 2021 | Knicks | 72 | Bucks | 96 |
| January | 19, 2021 | Knicks | 83 | Jazz | 102 |
| January | 22, 2021 | Knicks | 93 | Nuggets | 86 |
| January | 25, 2021 | Knicks | 88 | Lakers | 90 |
| January | 28, 2021 | Knicks | 108 | Trailblazers | 110 |
| January | 29, 2021 | Knicks | 84 | Warriors | 88 |
| February | 1, 2021 | Pacers | 110 | Knicks | 82 |
| February | 4, 2021 | 76ers | 106 | Knicks | 96 |
| February | 13, 2021 | Knicks | 95 | Wizards | 93 |
| February | 17, 2021 | Thunder | 94 | Knicks | 114 |
| February | 19, 2021 | Rockets | 89 | Knicks | 88 |
| February | 21, 2021 | Knicks | 113 | Nets | 107 |
| February | 23, 2021 | Heat | 80 | Knicks | 95 |
| February | 24, 2021 | Knicks | 86 | Hornets | 108 |
| February | 26, 2021 | Mavericks | 125 | Knicks | 87 |
| February | 28, 2021 | Celtics | 100 | Knicks | 108 |
| March | 3, 2021 | Grizzlies | 83 | Knicks | 108 |
| March | 5, 2021 | Pistons | 80 | Knicks | 100 |
| March | 8, 2021 | Knicks | 82 | Pistons | 111 |
| March | 9, 2021 | Raptors | 85 | Knicks | 102 |
| March | 11, 2021 | Knicks | 87 | Cavaliers | 80 |
| March | 13, 2021 | 76ers | 128 | Knicks | 121 |
| March | 14, 2021 | Knicks | 93 | Hawks | 99 |
| March | 16, 2021 | Wolves | 88 | Knicks | 97 |
| March | 18, 2021 | Spurs | 104 | Knicks | 98 |
| March | 20, 2021 | Magic | 93 | Knicks | 107 |
| March | 22, 2021 | Cavaliers | 89 | Knicks | 85 |
| March | 25, 2021 | Knicks | 88 | Clippers | 101 |
| March | 26, 2021 | Knicks | 102 | Kings | 114 |
| March | 28, 2021 | Knicks | 94 | Suns | 101 |
| March | 31, 2021 | Kings | 84 | Knicks | 68 |
| April | 1, 2021 | Knicks | 79 | Wolves | 84 |
| April | 3, 2021 | Knicks | 97 | Pacers | 106 |
| April | 6, 2021 | Knicks | 82 | Spurs | 120 |
| April | 8, 2021 | Lakers | 89 | Knicks | 105 |
| April | 9, 2021 | Knicks | 84 | Raptors | 83 |
| April | 11, 2021 | Jazz | 88 | Knicks | 74 |
| April | 13, 2021 | Nuggets | 91 | Knicks | 87 |
| April | 15, 2021 | Clippers | 96 | Knicks | 85 |
| April | 19, 2021 | Raptors | 78 | Knicks | 79 |
| April | 21, 2021 | Heat | 90 | Knicks | 102 |
| April | 23, 2021 | Bulls | 98 | Knicks | 87 |
| April | 25, 2021 | Knicks | 82 | Magic | 114 |
| April | 27, 2021 | Knicks | 96 | Rockets | 90 |
| April | 29, 2021 | Wizards | 91 | Knicks | 92 |
| April | 30, 2021 | Knicks | 80 | Bulls | 99 |
| May | 1, 2021 | Pistons | 86 | Knicks | 93 |