| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Cavaliers | 94 | Raptors | 106 |
| November | 6, 2020 | Cavaliers | 116 | Wolves | 122 |
| November | 8, 2020 | Hawks | 114 | Cavaliers | 116 |
| November | 11, 2020 | Nets | 94 | Cavaliers | 124 |
| November | 13, 2020 | Cavaliers | 113 | Pistons | 106 |
| November | 15, 2020 | Pacers | 130 | Cavaliers | 122 |
| November | 19, 2020 | Hawks | 89 | Cavaliers | 152 |
| November | 21, 2020 | Nuggets | 96 | Cavaliers | 133 |
| November | 23, 2020 | Cavaliers | 106 | Hornets | 85 |
| November | 25, 2020 | Cavaliers | 103 | Magic | 111 |
| November | 27, 2020 | Thunder | 103 | Cavaliers | 121 |
| November | 30, 2020 | Cavaliers | 135 | Bulls | 95 |
| December | 3, 2020 | Hornets | 91 | Cavaliers | 108 |
| December | 4, 2020 | Cavaliers | 107 | Wizards | 103 |
| December | 9, 2020 | Cavaliers | 110 | Pistons | 115 |
| December | 12, 2020 | Lakers | 105 | Cavaliers | 131 |
| December | 13, 2020 | Cavaliers | 121 | 76ers | 107 |
| December | 15, 2020 | Rockets | 117 | Cavaliers | 121 |
| December | 17, 2020 | Wolves | 111 | Cavaliers | 99 |
| December | 19, 2020 | Cavaliers | 134 | Thunder | 91 |
| December | 21, 2020 | Cavaliers | 102 | Celtics | 106 |
| December | 22, 2020 | Raptors | 131 | Cavaliers | 111 |
| December | 25, 2020 | Cavaliers | 110 | Nets | 112 |
| December | 27, 2020 | Warriors | 104 | Cavaliers | 113 |
| December | 29, 2020 | Kings | 101 | Cavaliers | 94 |
| December | 30, 2020 | Wizards | 110 | Cavaliers | 114 |
| January | 1, 2021 | Cavaliers | 115 | Bucks | 114 |
| January | 3, 2021 | Knicks | 94 | Cavaliers | 92 |
| January | 5, 2021 | Bucks | 108 | Cavaliers | 101 |
| January | 7, 2021 | 76ers | 111 | Cavaliers | 106 |
| January | 9, 2021 | Cavaliers | 115 | Pacers | 99 |
| January | 10, 2021 | Cavaliers | 91 | Hornets | 99 |
| January | 12, 2021 | Cavaliers | 102 | Raptors | 116 |
| January | 14, 2021 | Bulls | 114 | Cavaliers | 115 |
| January | 16, 2021 | Cavaliers | 118 | Grizzlies | 127 |
| January | 18, 2021 | Cavaliers | 99 | Heat | 95 |
| January | 19, 2021 | Cavaliers | 110 | Hawks | 105 |
| January | 23, 2021 | Heat | 85 | Cavaliers | 98 |
| January | 25, 2021 | Jazz | 96 | Cavaliers | 86 |
| January | 26, 2021 | Pelicans | 83 | Cavaliers | 108 |
| January | 29, 2021 | Pacers | 125 | Cavaliers | 106 |
| January | 30, 2021 | Cavaliers | 102 | Pelicans | 110 |
| February | 1, 2021 | Cavaliers | 99 | Rockets | 97 |
| February | 4, 2021 | Cavaliers | 75 | Lakers | 83 |
| February | 7, 2021 | Cavaliers | 106 | Trailblazers | 118 |
| February | 14, 2021 | Cavaliers | 93 | Jazz | 108 |
| February | 15, 2021 | Cavaliers | 108 | Nuggets | 80 |
| February | 17, 2021 | Bulls | 115 | Cavaliers | 112 |
| February | 19, 2021 | Cavaliers | 146 | Celtics | 108 |
| February | 21, 2021 | Heat | 79 | Cavaliers | 104 |
| February | 23, 2021 | Cavaliers | 116 | Bulls | 106 |
| February | 25, 2021 | Wizards | 86 | Cavaliers | 109 |
| March | 1, 2021 | Mavericks | 111 | Cavaliers | 96 |
| March | 5, 2021 | Celtics | 98 | Cavaliers | 107 |
| March | 8, 2021 | Cavaliers | 87 | Wizards | 123 |
| March | 9, 2021 | Cavaliers | 90 | Pacers | 96 |
| March | 11, 2021 | Knicks | 87 | Cavaliers | 80 |
| March | 13, 2021 | Nets | 99 | Cavaliers | 132 |
| March | 15, 2021 | Suns | 122 | Cavaliers | 101 |
| March | 17, 2021 | Grizzlies | 105 | Cavaliers | 124 |
| March | 19, 2021 | Trailblazers | 113 | Cavaliers | 129 |
| March | 22, 2021 | Cavaliers | 89 | Knicks | 85 |
| March | 24, 2021 | Pistons | 127 | Cavaliers | 91 |
| March | 25, 2021 | Magic | 81 | Cavaliers | 117 |
| March | 28, 2021 | Cavaliers | 121 | Nets | 86 |
| March | 30, 2021 | Cavaliers | 88 | Heat | 78 |
| April | 2, 2021 | Raptors | 108 | Cavaliers | 90 |
| April | 3, 2021 | Cavaliers | 113 | 76ers | 117 |
| April | 5, 2021 | Cavaliers | 110 | Magic | 99 |
| April | 7, 2021 | Cavaliers | 111 | Mavericks | 138 |
| April | 9, 2021 | Pistons | 121 | Cavaliers | 104 |
| April | 11, 2021 | Bucks | 119 | Cavaliers | 115 |
| April | 13, 2021 | Clippers | 108 | Cavaliers | 123 |
| April | 15, 2021 | Cavaliers | 117 | Bucks | 132 |
| April | 17, 2021 | Celtics | 77 | Cavaliers | 108 |
| April | 19, 2021 | Cavaliers | 98 | Spurs | 121 |
| April | 21, 2021 | Cavaliers | 89 | Clippers | 115 |
| April | 23, 2021 | Cavaliers | 91 | Suns | 111 |
| April | 26, 2021 | Cavaliers | 102 | Kings | 115 |
| April | 27, 2021 | Cavaliers | 80 | Warriors | 128 |
| April | 29, 2021 | Spurs | 124 | Cavaliers | 115 |
| April | 30, 2021 | Hornets | 67 | Cavaliers | 68 |
| Post | 1, 2021 | Cavaliers | 105 | Magic | 111 |
| Post | 2, 2021 | Cavaliers | 99 | Magic | 113 |
| Post | 3, 2021 | Magic | 104 | Cavaliers | 111 |
| Post | 4, 2021 | Magic | 117 | Cavaliers | 92 |
| Post | 5, 2021 | Cavaliers | 109 | Magic | 120 |
| Post | 6, 2021 | Magic | | Cavaliers | |
| Post | 7, 2021 | Cavaliers | | Magic | |