| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Kings | 98 | Trailblazers | 93 |
| November | 5, 2020 | Trailblazers | 75 | Mavericks | 122 |
| November | 8, 2020 | Trailblazers | 127 | Cavaliers | 135 |
| November | 10, 2020 | Trailblazers | 127 | Lakers | 136 |
| November | 13, 2020 | Trailblazers | 109 | Wolves | 116 |
| November | 15, 2020 | Wizards | 116 | Trailblazers | 105 |
| November | 17, 2020 | Suns | 115 | Trailblazers | 109 |
| November | 19, 2020 | Trailblazers | 119 | Nuggets | 130 |
| November | 21, 2020 | Bucks | 125 | Trailblazers | 93 |
| November | 23, 2020 | Trailblazers | 105 | Suns | 120 |
| November | 25, 2020 | Hawks | 117 | Trailblazers | 103 |
| November | 27, 2020 | Trailblazers | 94 | Spurs | 127 |
| November | 28, 2020 | Thunder | 137 | Trailblazers | 128 |
| November | 30, 2020 | Trailblazers | 119 | Pacers | 115 |
| December | 2, 2020 | Grizzlies | 106 | Trailblazers | 113 |
| December | 5, 2020 | Trailblazers | 109 | Heat | 108 |
| December | 6, 2020 | Trailblazers | 107 | 76ers | 117 |
| December | 8, 2020 | Trailblazers | 97 | Raptors | 140 |
| December | 11, 2020 | Rockets | 125 | Trailblazers | 105 |
| December | 13, 2020 | Clippers | 110 | Trailblazers | 103 |
| December | 15, 2020 | Trailblazers | 134 | Knicks | 124 |
| December | 17, 2020 | Trailblazers | 100 | Celtics | 109 |
| December | 20, 2020 | Celtics | 127 | Trailblazers | 110 |
| December | 21, 2020 | Trailblazers | 93 | Warriors | 112 |
| December | 23, 2020 | Pelicans | 102 | Trailblazers | 123 |
| December | 26, 2020 | Wolves | 100 | Trailblazers | 109 |
| December | 27, 2020 | Trailblazers | 132 | Suns | 110 |
| December | 29, 2020 | Mavericks | 102 | Trailblazers | 104 |
| December | 30, 2020 | Trailblazers | 112 | Jazz | 128 |
| January | 2, 2021 | Trailblazers | 81 | Kings | 91 |
| January | 5, 2021 | Clippers | 96 | Trailblazers | 118 |
| January | 8, 2021 | Lakers | 111 | Trailblazers | 119 |
| January | 10, 2021 | Trailblazers | 96 | Nuggets | 123 |
| January | 11, 2021 | Jazz | 96 | Trailblazers | 114 |
| January | 13, 2021 | Trailblazers | 91 | Magic | 131 |
| January | 15, 2021 | Trailblazers | 114 | Warriors | 117 |
| January | 18, 2021 | Trailblazers | 94 | Pistons | 123 |
| January | 21, 2021 | Trailblazers | 86 | Bulls | 130 |
| January | 23, 2021 | Trailblazers | 82 | Hornets | 96 |
| January | 25, 2021 | Rockets | 116 | Trailblazers | 81 |
| January | 28, 2021 | Trailblazers | 97 | Hawks | 125 |
| February | 1, 2021 | Spurs | 109 | Trailblazers | 111 |
| February | 4, 2021 | Lakers | 103 | Trailblazers | 94 |
| February | 7, 2021 | Mavericks | 133 | Trailblazers | 110 |
| February | 13, 2021 | Trailblazers | 108 | Wizards | 120 |
| February | 15, 2021 | Magic | 112 | Trailblazers | 117 |
| February | 17, 2021 | Pacers | 94 | Trailblazers | 96 |
| February | 18, 2021 | 76ers | 122 | Trailblazers | 101 |
| February | 20, 2021 | Trailblazers | 107 | Pelicans | 129 |
| February | 22, 2021 | Nets | 108 | Trailblazers | 106 |
| February | 25, 2021 | Nuggets | 115 | Trailblazers | 127 |
| February | 27, 2021 | Trailblazers | 99 | Kings | 85 |
| March | 1, 2021 | Raptors | 118 | Trailblazers | 101 |
| March | 3, 2021 | Trailblazers | 83 | Rockets | 124 |
| March | 4, 2021 | Grizzlies | 113 | Trailblazers | 126 |
| March | 6, 2021 | Trailblazers | 101 | Lakers | 142 |
| March | 9, 2021 | Warriors | 88 | Trailblazers | 91 |
| March | 12, 2021 | Heat | 130 | Trailblazers | 135 |
| March | 13, 2021 | Hornets | 85 | Trailblazers | 91 |
| March | 15, 2021 | Trailblazers | 97 | Mavericks | 122 |
| March | 18, 2021 | Warriors | 110 | Trailblazers | 94 |
| March | 21, 2021 | Cavaliers | 97 | Trailblazers | 103 |
| March | 24, 2021 | Trailblazers | 93 | Pelicans | 124 |
| March | 27, 2021 | Bulls | 109 | Trailblazers | 119 |
| March | 29, 2021 | Trailblazers | 111 | Grizzlies | 120 |
| March | 31, 2021 | Knicks | 100 | Trailblazers | 117 |
| April | 2, 2021 | Nuggets | 123 | Trailblazers | 105 |
| April | 4, 2021 | Trailblazers | 98 | Nets | 129 |
| April | 6, 2021 | Trailblazers | 85 | Spurs | 115 |
| April | 9, 2021 | Trailblazers | 102 | Thunder | 128 |
| April | 12, 2021 | Jazz | 109 | Trailblazers | 119 |
| April | 14, 2021 | Trailblazers | 107 | Bucks | 141 |
| April | 16, 2021 | Spurs | 101 | Trailblazers | 99 |
| April | 17, 2021 | Trailblazers | 121 | Grizzlies | 109 |
| April | 19, 2021 | Thunder | 116 | Trailblazers | 119 |
| April | 21, 2021 | Trailblazers | 110 | Clippers | 96 |
| April | 22, 2021 | Wolves | 127 | Trailblazers | 112 |
| April | 24, 2021 | Trailblazers | 107 | Jazz | 140 |
| April | 25, 2021 | Trailblazers | 97 | Rockets | 102 |
| April | 27, 2021 | Trailblazers | 126 | Clippers | 118 |
| April | 29, 2021 | Suns | 93 | Trailblazers | 119 |
| May | 1, 2021 | Pistons | 119 | Trailblazers | 117 |