| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Rockets | 116 | Spurs | 102 |
| November | 3, 2020 | Rockets | 91 | Mavericks | 74 |
| November | 6, 2020 | Pelicans | 91 | Rockets | 98 |
| November | 8, 2020 | Thunder | 99 | Rockets | 100 |
| November | 11, 2020 | Rockets | 103 | Nuggets | 91 |
| November | 13, 2020 | Pacers | 80 | Rockets | 116 |
| November | 14, 2020 | Kings | 85 | Rockets | 86 |
| November | 17, 2020 | Rockets | 92 | Bucks | 97 |
| November | 19, 2020 | Rockets | 109 | Wizards | 90 |
| November | 22, 2020 | Rockets | 104 | Hornets | 103 |
| November | 24, 2020 | Rockets | 112 | Bulls | 105 |
| November | 26, 2020 | Rockets | 89 | Suns | 105 |
| November | 28, 2020 | Grizzlies | 94 | Rockets | 108 |
| November | 30, 2020 | Rockets | 101 | Pelicans | 100 |
| December | 1, 2020 | Rockets | 103 | Jazz | 100 |
| December | 3, 2020 | Rockets | 97 | Wolves | 98 |
| December | 6, 2020 | Hawks | 83 | Rockets | 80 |
| December | 8, 2020 | Clippers | 97 | Rockets | 113 |
| December | 9, 2020 | Celtics | 71 | Rockets | 100 |
| December | 11, 2020 | Rockets | 125 | Trailblazers | 105 |
| December | 12, 2020 | Spurs | 84 | Rockets | 121 |
| December | 14, 2020 | Nuggets | 85 | Rockets | 108 |
| December | 17, 2020 | Rockets | 112 | 76ers | 98 |
| December | 18, 2020 | Rockets | 99 | Knicks | 94 |
| December | 21, 2020 | Rockets | 126 | Cavaliers | 128 |
| December | 23, 2020 | Heat | 86 | Rockets | 108 |
| December | 26, 2020 | Suns | 104 | Rockets | 116 |
| December | 29, 2020 | Rockets | 98 | Pistons | 122 |
| December | 31, 2020 | Rockets | 85 | Pacers | 80 |
| January | 1, 2021 | Warriors | 95 | Rockets | 97 |
| January | 3, 2021 | Magic | 73 | Rockets | 83 |
| January | 6, 2021 | Rockets | 91 | Lakers | 93 |
| January | 8, 2021 | Rockets | 94 | Thunder | 105 |
| January | 11, 2021 | Rockets | 94 | Spurs | 99 |
| January | 13, 2021 | Nuggets | 82 | Rockets | 81 |
| January | 15, 2021 | Rockets | 107 | Nets | 97 |
| January | 16, 2021 | Rockets | 90 | Celtics | 80 |
| January | 18, 2021 | Rockets | 94 | Warriors | 115 |
| January | 20, 2021 | Mavericks | 98 | Rockets | 100 |
| January | 21, 2021 | Raptors | 96 | Rockets | 92 |
| January | 23, 2021 | Bucks | 96 | Rockets | 121 |
| January | 25, 2021 | Rockets | 116 | Trailblazers | 81 |
| January | 27, 2021 | Lakers | 95 | Rockets | 103 |
| January | 29, 2021 | Hornets | 65 | Rockets | 91 |
| January | 31, 2021 | Clippers | 119 | Rockets | 110 |
| February | 2, 2021 | Rockets | 93 | Warriors | 117 |
| February | 5, 2021 | Rockets | 90 | Magic | 95 |
| February | 6, 2021 | Rockets | 96 | Raptors | 112 |
| February | 13, 2021 | Pistons | 100 | Rockets | 106 |
| February | 16, 2021 | Wizards | 99 | Rockets | 81 |
| February | 19, 2021 | Rockets | 80 | Mavericks | 81 |
| February | 21, 2021 | Rockets | 86 | Grizzlies | 94 |
| February | 23, 2021 | Knicks | 54 | Rockets | 95 |
| February | 25, 2021 | Nets | 118 | Rockets | 124 |
| February | 27, 2021 | Spurs | 87 | Rockets | 99 |
| March | 2, 2021 | Rockets | 102 | Clippers | 99 |
| March | 3, 2021 | Trailblazers | 83 | Rockets | 124 |
| March | 6, 2021 | Rockets | 91 | Heat | 83 |
| March | 9, 2021 | Rockets | 92 | Hawks | 90 |
| March | 11, 2021 | Jazz | 94 | Rockets | 80 |
| March | 13, 2021 | Rockets | 98 | Wolves | 93 |
| March | 15, 2021 | Thunder | 106 | Rockets | 99 |
| March | 17, 2021 | Cavaliers | 93 | Rockets | 80 |
| March | 18, 2021 | Rockets | 77 | Nuggets | 97 |
| March | 21, 2021 | Kings | 89 | Rockets | 86 |
| March | 24, 2021 | Warriors | 84 | Rockets | 107 |
| March | 27, 2021 | Rockets | 92 | Lakers | 104 |
| March | 30, 2021 | 76ers | 98 | Rockets | 110 |
| April | 1, 2021 | Rockets | 91 | Pelicans | 88 |
| April | 2, 2021 | Lakers | 112 | Rockets | 114 |
| April | 4, 2021 | Bulls | 105 | Rockets | 112 |
| April | 7, 2021 | Rockets | 77 | Kings | 70 |
| April | 9, 2021 | Suns | 87 | Rockets | 103 |
| April | 12, 2021 | Mavericks | 74 | Rockets | 101 |
| April | 15, 2021 | Wolves | 86 | Rockets | 91 |
| April | 18, 2021 | Rockets | 92 | Thunder | 100 |
| April | 20, 2021 | Jazz | 92 | Rockets | 91 |
| April | 22, 2021 | Pelicans | 94 | Rockets | 108 |
| April | 23, 2021 | Rockets | 113 | Grizzlies | 100 |
| April | 25, 2021 | Trailblazers | 97 | Rockets | 102 |
| April | 28, 2021 | Rockets | 99 | Suns | 83 |
| May | 1, 2021 | Rockets | 91 | Jazz | 89 |
| Post | 1, 2021 | Mavericks | 102 | Rockets | 69 |
| Post | 2, 2021 | Mavericks | 89 | Rockets | 105 |
| Post | 3, 2021 | Rockets | 81 | Mavericks | 89 |
| Post | 4, 2021 | Rockets | 96 | Mavericks | 94 |
| Post | 5, 2021 | Mavericks | 84 | Rockets | 101 |
| Post | 6, 2021 | Rockets | 102 | Mavericks | 74 |
| Post | 7, 2021 | Mavericks | | Rockets | |
| Post | 8, 2021 | Warriors | 111 | Rockets | 84 |
| Post | 9, 2021 | Warriors | 81 | Rockets | 96 |
| Post | 10, 2021 | Rockets | 95 | Warriors | 117 |
| Post | 11, 2021 | Rockets | 84 | Warriors | 88 |
| Post | 12, 2021 | Warriors | 91 | Rockets | 87 |
| Post | 13, 2021 | Rockets | | Warriors | |
| Post | 14, 2021 | Warriors | | Rockets | |