| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Clippers | 120 | Lakers | 130 |
| November | 5, 2020 | Lakers | 102 | Jazz | 122 |
| November | 7, 2020 | Thunder | 99 | Lakers | 133 |
| November | 10, 2020 | Trailblazers | 127 | Lakers | 136 |
| November | 12, 2020 | Lakers | 115 | Knicks | 104 |
| November | 15, 2020 | Lakers | 139 | Nets | 116 |
| November | 17, 2020 | Nuggets | 107 | Lakers | 112 |
| November | 19, 2020 | Lakers | 100 | Spurs | 128 |
| November | 21, 2020 | Raptors | 121 | Lakers | 122 |
| November | 24, 2020 | Lakers | 95 | Warriors | 106 |
| November | 26, 2020 | Wolves | 95 | Lakers | 98 |
| November | 28, 2020 | Lakers | 115 | Celtics | 105 |
| November | 30, 2020 | Lakers | 104 | Wizards | 106 |
| December | 2, 2020 | Lakers | 87 | Kings | 106 |
| December | 4, 2020 | Mavericks | 105 | Lakers | 102 |
| December | 7, 2020 | Pistons | 131 | Lakers | 101 |
| December | 8, 2020 | Knicks | 100 | Lakers | 116 |
| December | 10, 2020 | Grizzlies | 118 | Lakers | 115 |
| December | 12, 2020 | Lakers | 125 | Suns | 109 |
| December | 15, 2020 | Pacers | 117 | Lakers | 119 |
| December | 17, 2020 | Magic | 100 | Lakers | 110 |
| December | 18, 2020 | Lakers | 96 | Jazz | 105 |
| December | 20, 2020 | Cavaliers | 118 | Lakers | 141 |
| December | 22, 2020 | Lakers | 93 | Thunder | 129 |
| December | 25, 2020 | Spurs | 123 | Lakers | 106 |
| December | 28, 2020 | Pelicans | 108 | Lakers | 80 |
| December | 30, 2020 | Lakers | 87 | Hornets | 98 |
| January | 1, 2021 | Lakers | 84 | Hawks | 103 |
| January | 4, 2021 | Lakers | 110 | Raptors | 120 |
| January | 6, 2021 | Rockets | 91 | Lakers | 93 |
| January | 8, 2021 | Lakers | 111 | Trailblazers | 119 |
| January | 10, 2021 | Heat | 113 | Lakers | 87 |
| January | 12, 2021 | Lakers | 80 | Mavericks | 108 |
| January | 16, 2021 | Lakers | 99 | Bulls | 119 |
| January | 19, 2021 | Lakers | 108 | 76ers | 90 |
| January | 20, 2021 | Lakers | 108 | Bucks | 105 |
| January | 21, 2021 | Hawks | 98 | Lakers | 101 |
| January | 24, 2021 | Spurs | 120 | Lakers | 121 |
| January | 27, 2021 | Lakers | 95 | Rockets | 103 |
| January | 28, 2021 | Kings | 96 | Lakers | 84 |
| January | 31, 2021 | Lakers | 89 | Grizzlies | 138 |
| February | 1, 2021 | Lakers | 114 | Nuggets | 133 |
| February | 4, 2021 | Lakers | 103 | Trailblazers | 94 |
| February | 5, 2021 | Lakers | 109 | Clippers | 116 |
| February | 7, 2021 | Hornets | 76 | Lakers | 91 |
| February | 14, 2021 | Suns | 72 | Lakers | 94 |
| February | 17, 2021 | Lakers | 112 | Cavaliers | 143 |
| February | 18, 2021 | Lakers | 83 | Pistons | 120 |
| February | 20, 2021 | Celtics | 93 | Lakers | 129 |
| February | 22, 2021 | Lakers | 107 | Pelicans | 132 |
| February | 24, 2021 | Warriors | 119 | Lakers | 110 |
| February | 26, 2021 | Lakers | 111 | Wolves | 132 |
| February | 28, 2021 | Wizards | 121 | Lakers | 118 |
| March | 2, 2021 | Lakers | 134 | Heat | 133 |
| March | 3, 2021 | Lakers | 113 | Magic | 124 |
| March | 6, 2021 | Trailblazers | 101 | Lakers | 142 |
| March | 7, 2021 | Lakers | 122 | Thunder | 120 |
| March | 9, 2021 | Pelicans | 143 | Lakers | 95 |
| March | 12, 2021 | Lakers | 128 | Pacers | 112 |
| March | 15, 2021 | Lakers | 129 | Spurs | 123 |
| March | 16, 2021 | Kings | 84 | Lakers | 97 |
| March | 19, 2021 | Lakers | 128 | Warriors | 101 |
| March | 22, 2021 | 76ers | 122 | Lakers | 91 |
| March | 24, 2021 | Suns | 105 | Lakers | 129 |
| March | 27, 2021 | Rockets | 92 | Lakers | 104 |
| March | 28, 2021 | Lakers | 117 | Nuggets | 125 |
| March | 30, 2021 | Jazz | 103 | Lakers | 93 |
| April | 1, 2021 | Lakers | 132 | Wolves | 98 |
| April | 2, 2021 | Lakers | 112 | Rockets | 114 |
| April | 4, 2021 | Thunder | 101 | Lakers | 111 |
| April | 7, 2021 | Lakers | 96 | Mavericks | 102 |
| April | 10, 2021 | Nets | 113 | Lakers | 115 |
| April | 13, 2021 | Lakers | 87 | Kings | 113 |
| April | 14, 2021 | Grizzlies | 99 | Lakers | 128 |
| April | 16, 2021 | Bucks | 108 | Lakers | 101 |
| April | 19, 2021 | Bulls | 117 | Lakers | 119 |
| April | 21, 2021 | Mavericks | 110 | Lakers | 100 |
| April | 24, 2021 | Lakers | 98 | Clippers | 96 |
| April | 25, 2021 | Lakers | 77 | Pelicans | 103 |
| April | 27, 2021 | Nuggets | 83 | Lakers | 95 |
| April | 28, 2021 | Warriors | 123 | Lakers | 106 |
| May | 1, 2021 | Wolves | 103 | Lakers | 110 |