| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Suns | 112 | Grizzlies | 100 |
| November | 4, 2020 | Grizzlies | 104 | Nuggets | 122 |
| November | 7, 2020 | Wolves | 102 | Grizzlies | 128 |
| November | 9, 2020 | Grizzlies | 74 | Kings | 106 |
| November | 10, 2020 | Grizzlies | 115 | Hornets | 112 |
| November | 12, 2020 | Heat | 99 | Grizzlies | 138 |
| November | 14, 2020 | Grizzlies | 105 | Bulls | 112 |
| November | 15, 2020 | Grizzlies | 93 | Bucks | 124 |
| November | 18, 2020 | Grizzlies | 112 | Hawks | 92 |
| November | 21, 2020 | Grizzlies | 128 | Pistons | 120 |
| November | 24, 2020 | Clippers | 121 | Grizzlies | 120 |
| November | 25, 2020 | Mavericks | 86 | Grizzlies | 114 |
| November | 28, 2020 | Grizzlies | 94 | Rockets | 108 |
| November | 30, 2020 | 76ers | 124 | Grizzlies | 96 |
| December | 2, 2020 | Grizzlies | 106 | Trailblazers | 113 |
| December | 4, 2020 | Nets | 115 | Grizzlies | 106 |
| December | 5, 2020 | Jazz | 115 | Grizzlies | 113 |
| December | 8, 2020 | Grizzlies | 103 | Warriors | 128 |
| December | 10, 2020 | Grizzlies | 118 | Lakers | 115 |
| December | 12, 2020 | Celtics | 92 | Grizzlies | 105 |
| December | 15, 2020 | Grizzlies | 124 | 76ers | 113 |
| December | 17, 2020 | Grizzlies | 138 | Cavaliers | 125 |
| December | 20, 2020 | Grizzlies | 124 | Wizards | 120 |
| December | 22, 2020 | Magic | 103 | Grizzlies | 105 |
| December | 26, 2020 | Grizzlies | 103 | Mavericks | 112 |
| December | 29, 2020 | Thunder | 122 | Grizzlies | 120 |
| January | 1, 2021 | Grizzlies | 129 | Wolves | 105 |
| January | 3, 2021 | Pistons | 121 | Grizzlies | 132 |
| January | 4, 2021 | Warriors | 113 | Grizzlies | 110 |
| January | 7, 2021 | Pelicans | 102 | Grizzlies | 107 |
| January | 8, 2021 | Grizzlies | 123 | Spurs | 138 |
| January | 10, 2021 | Bucks | 103 | Grizzlies | 123 |
| January | 13, 2021 | Grizzlies | 131 | Nets | 112 |
| January | 16, 2021 | Grizzlies | 115 | Heat | 128 |
| January | 18, 2021 | Raptors | 113 | Grizzlies | 118 |
| January | 21, 2021 | Grizzlies | 115 | Jazz | 118 |
| January | 23, 2021 | Cavaliers | 109 | Grizzlies | 122 |
| January | 25, 2021 | Grizzlies | 92 | Suns | 112 |
| January | 28, 2021 | Grizzlies | 107 | Knicks | 101 |
| January | 30, 2021 | Grizzlies | 98 | Raptors | 133 |
| January | 31, 2021 | Lakers | 89 | Grizzlies | 138 |
| February | 4, 2021 | Suns | 138 | Grizzlies | 117 |
| February | 6, 2021 | Nuggets | 105 | Grizzlies | 112 |
| February | 14, 2021 | Grizzlies | 112 | Clippers | 125 |
| February | 15, 2021 | Grizzlies | 136 | Warriors | 131 |
| February | 17, 2021 | Grizzlies | 109 | Pelicans | 131 |
| February | 18, 2021 | Nuggets | 106 | Grizzlies | 111 |
| February | 21, 2021 | Rockets | 86 | Grizzlies | 94 |
| February | 24, 2021 | Bulls | 111 | Grizzlies | 123 |
| February | 27, 2021 | Grizzlies | 89 | Jazz | 119 |
| February | 28, 2021 | Grizzlies | 115 | Thunder | 130 |
| March | 2, 2021 | Jazz | 120 | Grizzlies | 113 |
| March | 4, 2021 | Grizzlies | 113 | Trailblazers | 126 |
| March | 7, 2021 | Hornets | 91 | Grizzlies | 101 |
| March | 10, 2021 | Knicks | 109 | Grizzlies | 125 |
| March | 12, 2021 | Grizzlies | 114 | Spurs | 120 |
| March | 14, 2021 | Wizards | 106 | Grizzlies | 131 |
| March | 16, 2021 | Warriors | 101 | Grizzlies | 116 |
| March | 19, 2021 | Pelicans | 127 | Grizzlies | 117 |
| March | 21, 2021 | Grizzlies | 107 | Mavericks | 103 |
| March | 24, 2021 | Hawks | 128 | Grizzlies | 103 |
| March | 27, 2021 | Grizzlies | 119 | Clippers | 117 |
| March | 29, 2021 | Trailblazers | 111 | Grizzlies | 120 |
| March | 31, 2021 | Kings | 91 | Grizzlies | 116 |
| April | 2, 2021 | Grizzlies | 124 | Magic | 120 |
| April | 4, 2021 | Grizzlies | 112 | Celtics | 108 |
| April | 5, 2021 | Grizzlies | 113 | Pacers | 127 |
| April | 7, 2021 | Wolves | 102 | Grizzlies | 104 |
| April | 8, 2021 | Grizzlies | 112 | Pelicans | 149 |
| April | 10, 2021 | Pacers | 126 | Grizzlies | 122 |
| April | 13, 2021 | Grizzlies | 120 | Wolves | 129 |
| April | 14, 2021 | Grizzlies | 99 | Lakers | 128 |
| April | 16, 2021 | Clippers | 109 | Grizzlies | 124 |
| April | 17, 2021 | Trailblazers | 121 | Grizzlies | 109 |
| April | 19, 2021 | Grizzlies | 99 | Kings | 110 |
| April | 21, 2021 | Spurs | 138 | Grizzlies | 118 |
| April | 23, 2021 | Rockets | 113 | Grizzlies | 100 |
| April | 25, 2021 | Grizzlies | 116 | Nuggets | 122 |
| April | 26, 2021 | Mavericks | 120 | Grizzlies | 109 |
| April | 28, 2021 | Grizzlies | 102 | Thunder | 119 |
| April | 30, 2021 | Spurs | 127 | Grizzlies | 112 |
| May | 1, 2021 | Kings | 110 | Grizzlies | 102 |