| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Heat | 106 | Cavaliers | 126 |
| November | 4, 2020 | Cavaliers | 123 | Wolves | 84 |
| November | 6, 2020 | Cavaliers | 90 | Hornets | 95 |
| November | 8, 2020 | Trailblazers | 127 | Cavaliers | 135 |
| November | 10, 2020 | Cavaliers | 101 | Bucks | 109 |
| November | 12, 2020 | Cavaliers | 96 | Kings | 93 |
| November | 13, 2020 | Magic | 110 | Cavaliers | 122 |
| November | 15, 2020 | Warriors | 114 | Cavaliers | 93 |
| November | 16, 2020 | Cavaliers | 105 | 76ers | 119 |
| November | 18, 2020 | Cavaliers | 113 | Knicks | 136 |
| November | 20, 2020 | Bucks | 110 | Cavaliers | 109 |
| November | 22, 2020 | Cavaliers | 118 | Raptors | 132 |
| November | 25, 2020 | Thunder | 116 | Cavaliers | 107 |
| November | 26, 2020 | Wizards | 114 | Cavaliers | 117 |
| November | 28, 2020 | Cavaliers | 119 | Nets | 108 |
| November | 30, 2020 | Suns | 107 | Cavaliers | 137 |
| December | 2, 2020 | Cavaliers | 93 | Hornets | 130 |
| December | 5, 2020 | Celtics | 108 | Cavaliers | 105 |
| December | 8, 2020 | Magic | 116 | Cavaliers | 142 |
| December | 10, 2020 | Cavaliers | 132 | Clippers | 134 |
| December | 13, 2020 | Cavaliers | 103 | Heat | 123 |
| December | 15, 2020 | Jazz | 106 | Cavaliers | 118 |
| December | 17, 2020 | Grizzlies | 138 | Cavaliers | 125 |
| December | 20, 2020 | Cavaliers | 118 | Lakers | 141 |
| December | 21, 2020 | Rockets | 126 | Cavaliers | 128 |
| December | 25, 2020 | Cavaliers | 101 | Mavericks | 116 |
| December | 26, 2020 | Cavaliers | 123 | Pelicans | 131 |
| December | 28, 2020 | Pacers | 115 | Cavaliers | 124 |
| December | 30, 2020 | Hawks | 95 | Cavaliers | 98 |
| January | 2, 2021 | Cavaliers | 107 | Spurs | 138 |
| January | 4, 2021 | Cavaliers | 111 | Bulls | 106 |
| January | 6, 2021 | Kings | 108 | Cavaliers | 120 |
| January | 9, 2021 | Cavaliers | 115 | Celtics | 77 |
| January | 12, 2021 | Pistons | 109 | Cavaliers | 120 |
| January | 15, 2021 | Cavaliers | 124 | Hawks | 102 |
| January | 18, 2021 | Hornets | 83 | Cavaliers | 85 |
| January | 21, 2021 | Wolves | 101 | Cavaliers | 119 |
| January | 23, 2021 | Cavaliers | 109 | Grizzlies | 122 |
| January | 25, 2021 | Nuggets | 111 | Cavaliers | 123 |
| January | 26, 2021 | Pelicans | 84 | Cavaliers | 85 |
| January | 29, 2021 | 76ers | 96 | Cavaliers | 102 |
| February | 1, 2021 | Cavaliers | 105 | Hawks | 114 |
| February | 4, 2021 | Mavericks | 95 | Cavaliers | 110 |
| February | 6, 2021 | Cavaliers | 123 | Heat | 93 |
| February | 14, 2021 | Cavaliers | 131 | Bulls | 135 |
| February | 17, 2021 | Lakers | 112 | Cavaliers | 143 |
| February | 20, 2021 | Raptors | 122 | Cavaliers | 109 |
| February | 23, 2021 | Raptors | 120 | Cavaliers | 117 |
| February | 26, 2021 | Cavaliers | 94 | Wizards | 108 |
| March | 1, 2021 | Knicks | 109 | Cavaliers | 127 |
| March | 2, 2021 | Cavaliers | 119 | Nuggets | 115 |
| March | 4, 2021 | Cavaliers | 94 | Jazz | 118 |
| March | 7, 2021 | Bucks | 108 | Cavaliers | 132 |
| March | 9, 2021 | Hornets | 92 | Cavaliers | 93 |
| March | 11, 2021 | Cavaliers | 132 | Wizards | 120 |
| March | 12, 2021 | 76ers | 89 | Cavaliers | 108 |
| March | 14, 2021 | Cavaliers | 101 | Warriors | 124 |
| March | 15, 2021 | Clippers | 90 | Cavaliers | 139 |
| March | 17, 2021 | Cavaliers | 93 | Rockets | 80 |
| March | 18, 2021 | Celtics | 104 | Cavaliers | 132 |
| March | 21, 2021 | Cavaliers | 97 | Trailblazers | 103 |
| March | 24, 2021 | Pistons | 116 | Cavaliers | 121 |
| March | 26, 2021 | Cavaliers | 112 | Nets | 115 |
| March | 27, 2021 | Cavaliers | 92 | Thunder | 115 |
| March | 29, 2021 | Cavaliers | 95 | Knicks | 100 |
| March | 30, 2021 | Pacers | 106 | Cavaliers | 122 |
| April | 2, 2021 | Spurs | 117 | Cavaliers | 100 |
| April | 4, 2021 | Cavaliers | 132 | Pacers | 129 |
| April | 6, 2021 | Nets | 103 | Cavaliers | 109 |
| April | 9, 2021 | Nets | 98 | Cavaliers | 121 |
| April | 11, 2021 | Cavaliers | 95 | Suns | 101 |
| April | 14, 2021 | Heat | 120 | Cavaliers | 127 |
| April | 16, 2021 | Bulls | 110 | Cavaliers | 106 |
| April | 17, 2021 | Cavaliers | 105 | Pistons | 121 |
| April | 19, 2021 | Cavaliers | 123 | 76ers | 111 |
| April | 21, 2021 | Cavaliers | 116 | Magic | 113 |
| April | 22, 2021 | Wizards | 91 | Cavaliers | 114 |
| April | 25, 2021 | Hawks | 107 | Cavaliers | 120 |
| April | 27, 2021 | Cavaliers | 116 | Raptors | 110 |
| April | 28, 2021 | Cavaliers | 105 | Celtics | 101 |
| April | 30, 2021 | Cavaliers | 109 | Bucks | 102 |
| May | 1, 2021 | Cavaliers | 113 | Magic | 125 |
| Post | 1, 2021 | Cavaliers | 71 | Bucks | 92 |
| Post | 2, 2021 | Cavaliers | 86 | Bucks | 97 |
| Post | 3, 2021 | Bucks | 81 | Cavaliers | 85 |
| Post | 4, 2021 | Bucks | 123 | Cavaliers | 107 |
| Post | 5, 2021 | Cavaliers | 117 | Bucks | 111 |
| Post | 6, 2021 | Bucks | 104 | Cavaliers | 107 |
| Post | 7, 2021 | Cavaliers | 126 | Bucks | 102 |
| Post | 8, 2021 | Cavaliers | 91 | Pistons | 122 |
| Post | 9, 2021 | Cavaliers | 128 | Pistons | 125 |
| Post | 10, 2021 | Pistons | 118 | Cavaliers | 110 |
| Post | 11, 2021 | Pistons | 110 | Cavaliers | 92 |
| Post | 12, 2021 | Cavaliers | 97 | Pistons | 112 |
| Post | 13, 2021 | Pistons | | Cavaliers | |
| Post | 14, 2021 | Cavaliers | | Pistons | |