| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Kings | 111 | Trailblazers | 116 |
| November | 5, 2020 | Trailblazers | 112 | Mavericks | 125 |
| November | 8, 2020 | Trailblazers | 128 | Cavaliers | 114 |
| November | 10, 2020 | Trailblazers | 92 | Lakers | 126 |
| November | 13, 2020 | Trailblazers | 97 | Wolves | 112 |
| November | 15, 2020 | Wizards | 116 | Trailblazers | 101 |
| November | 17, 2020 | Suns | 96 | Trailblazers | 126 |
| November | 19, 2020 | Trailblazers | 109 | Nuggets | 117 |
| November | 21, 2020 | Bucks | 128 | Trailblazers | 112 |
| November | 23, 2020 | Trailblazers | 115 | Suns | 106 |
| November | 25, 2020 | Hawks | 103 | Trailblazers | 117 |
| November | 27, 2020 | Trailblazers | 103 | Spurs | 142 |
| November | 28, 2020 | Thunder | 114 | Trailblazers | 122 |
| November | 30, 2020 | Trailblazers | 118 | Pacers | 105 |
| December | 2, 2020 | Grizzlies | 117 | Trailblazers | 130 |
| December | 5, 2020 | Trailblazers | 113 | Heat | 107 |
| December | 6, 2020 | Trailblazers | 107 | 76ers | 110 |
| December | 8, 2020 | Trailblazers | 115 | Raptors | 133 |
| December | 11, 2020 | Rockets | 112 | Trailblazers | 114 |
| December | 13, 2020 | Clippers | 114 | Trailblazers | 123 |
| December | 15, 2020 | Trailblazers | 131 | Knicks | 136 |
| December | 17, 2020 | Trailblazers | 118 | Celtics | 130 |
| December | 20, 2020 | Celtics | 133 | Trailblazers | 104 |
| December | 21, 2020 | Trailblazers | 100 | Warriors | 145 |
| December | 23, 2020 | Pelicans | 106 | Trailblazers | 92 |
| December | 26, 2020 | Wolves | 109 | Trailblazers | 122 |
| December | 27, 2020 | Trailblazers | 100 | Suns | 120 |
| December | 29, 2020 | Mavericks | 106 | Trailblazers | 104 |
| December | 30, 2020 | Trailblazers | 101 | Jazz | 112 |
| January | 2, 2021 | Trailblazers | 118 | Kings | 120 |
| January | 5, 2021 | Clippers | 110 | Trailblazers | 119 |
| January | 8, 2021 | Lakers | 149 | Trailblazers | 128 |
| January | 10, 2021 | Trailblazers | 107 | Nuggets | 104 |
| January | 11, 2021 | Jazz | 129 | Trailblazers | 136 |
| January | 13, 2021 | Trailblazers | 113 | Magic | 120 |
| January | 15, 2021 | Trailblazers | 104 | Warriors | 153 |
| January | 18, 2021 | Trailblazers | 111 | Pistons | 131 |
| January | 21, 2021 | Trailblazers | 96 | Bulls | 124 |
| January | 23, 2021 | Trailblazers | 76 | Hornets | 104 |
| January | 25, 2021 | Rockets | 130 | Trailblazers | 101 |
| January | 28, 2021 | Trailblazers | 122 | Hawks | 129 |
| February | 1, 2021 | Spurs | 131 | Trailblazers | 106 |
| February | 4, 2021 | Lakers | 102 | Trailblazers | 121 |
| February | 7, 2021 | Mavericks | 103 | Trailblazers | 95 |
| February | 13, 2021 | Trailblazers | 125 | Wizards | 131 |
| February | 15, 2021 | Magic | 115 | Trailblazers | 110 |
| February | 17, 2021 | Pacers | 114 | Trailblazers | 112 |
| February | 18, 2021 | 76ers | 133 | Trailblazers | 103 |
| February | 20, 2021 | Trailblazers | 116 | Pelicans | 124 |
| February | 22, 2021 | Nets | 104 | Trailblazers | 113 |
| February | 25, 2021 | Nuggets | 132 | Trailblazers | 106 |
| February | 27, 2021 | Trailblazers | 110 | Kings | 133 |
| March | 1, 2021 | Raptors | 119 | Trailblazers | 112 |
| March | 3, 2021 | Trailblazers | 101 | Rockets | 151 |
| March | 4, 2021 | Grizzlies | 94 | Trailblazers | 123 |
| March | 6, 2021 | Trailblazers | 91 | Lakers | 132 |
| March | 9, 2021 | Warriors | 136 | Trailblazers | 122 |
| March | 12, 2021 | Heat | 123 | Trailblazers | 132 |
| March | 13, 2021 | Hornets | 121 | Trailblazers | 116 |
| March | 15, 2021 | Trailblazers | 96 | Mavericks | 126 |
| March | 18, 2021 | Warriors | 132 | Trailblazers | 115 |
| March | 21, 2021 | Cavaliers | 124 | Trailblazers | 110 |
| March | 24, 2021 | Trailblazers | 104 | Pelicans | 127 |
| March | 27, 2021 | Bulls | 122 | Trailblazers | 114 |
| March | 29, 2021 | Trailblazers | 118 | Grizzlies | 144 |
| March | 31, 2021 | Knicks | 126 | Trailblazers | 123 |
| April | 2, 2021 | Nuggets | 115 | Trailblazers | 105 |
| April | 4, 2021 | Trailblazers | 118 | Nets | 127 |
| April | 6, 2021 | Trailblazers | 102 | Spurs | 131 |
| April | 9, 2021 | Trailblazers | 111 | Thunder | 109 |
| April | 12, 2021 | Jazz | 111 | Trailblazers | 103 |
| April | 14, 2021 | Trailblazers | 112 | Bucks | 114 |
| April | 16, 2021 | Spurs | 122 | Trailblazers | 126 |
| April | 17, 2021 | Trailblazers | 105 | Grizzlies | 115 |
| April | 19, 2021 | Thunder | 125 | Trailblazers | 133 |
| April | 21, 2021 | Trailblazers | 122 | Clippers | 119 |
| April | 22, 2021 | Wolves | 110 | Trailblazers | 113 |
| April | 24, 2021 | Trailblazers | 123 | Jazz | 115 |
| April | 25, 2021 | Trailblazers | 97 | Rockets | 131 |
| April | 27, 2021 | Trailblazers | 115 | Clippers | 91 |
| April | 29, 2021 | Suns | 122 | Trailblazers | 108 |
| May | 1, 2021 | Pistons | 127 | Trailblazers | 114 |