| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Rockets | 87 | Spurs | 91 |
| November | 3, 2020 | Rockets | 115 | Mavericks | 117 |
| November | 6, 2020 | Pelicans | 77 | Rockets | 97 |
| November | 8, 2020 | Thunder | 99 | Rockets | 94 |
| November | 11, 2020 | Rockets | 91 | Nuggets | 119 |
| November | 13, 2020 | Pacers | 100 | Rockets | 118 |
| November | 14, 2020 | Kings | 101 | Rockets | 98 |
| November | 17, 2020 | Rockets | 107 | Bucks | 88 |
| November | 19, 2020 | Rockets | 87 | Wizards | 114 |
| November | 22, 2020 | Rockets | 85 | Hornets | 94 |
| November | 24, 2020 | Rockets | 110 | Bulls | 74 |
| November | 26, 2020 | Rockets | 98 | Suns | 69 |
| November | 28, 2020 | Grizzlies | 100 | Rockets | 106 |
| November | 30, 2020 | Rockets | 102 | Pelicans | 95 |
| December | 1, 2020 | Rockets | 93 | Jazz | 96 |
| December | 3, 2020 | Rockets | 86 | Wolves | 109 |
| December | 6, 2020 | Hawks | 82 | Rockets | 102 |
| December | 8, 2020 | Clippers | 88 | Rockets | 104 |
| December | 9, 2020 | Celtics | 101 | Rockets | 123 |
| December | 11, 2020 | Rockets | 112 | Trailblazers | 114 |
| December | 12, 2020 | Spurs | 118 | Rockets | 106 |
| December | 14, 2020 | Nuggets | 83 | Rockets | 104 |
| December | 17, 2020 | Rockets | 94 | 76ers | 104 |
| December | 18, 2020 | Rockets | 89 | Knicks | 93 |
| December | 21, 2020 | Rockets | 110 | Cavaliers | 105 |
| December | 23, 2020 | Heat | 92 | Rockets | 116 |
| December | 26, 2020 | Suns | 97 | Rockets | 108 |
| December | 29, 2020 | Rockets | 88 | Pistons | 112 |
| December | 31, 2020 | Rockets | 83 | Pacers | 88 |
| January | 1, 2021 | Warriors | 97 | Rockets | 96 |
| January | 3, 2021 | Magic | 119 | Rockets | 117 |
| January | 6, 2021 | Rockets | 132 | Lakers | 130 |
| January | 8, 2021 | Rockets | 124 | Thunder | 103 |
| January | 11, 2021 | Rockets | 101 | Spurs | 106 |
| January | 13, 2021 | Nuggets | 88 | Rockets | 119 |
| January | 15, 2021 | Rockets | 99 | Nets | 79 |
| January | 16, 2021 | Rockets | 105 | Celtics | 123 |
| January | 18, 2021 | Rockets | 120 | Warriors | 84 |
| January | 20, 2021 | Mavericks | 78 | Rockets | 100 |
| January | 21, 2021 | Raptors | 115 | Rockets | 105 |
| January | 23, 2021 | Bucks | 77 | Rockets | 78 |
| January | 25, 2021 | Rockets | 130 | Trailblazers | 101 |
| January | 27, 2021 | Lakers | 92 | Rockets | 111 |
| January | 29, 2021 | Hornets | 87 | Rockets | 102 |
| January | 31, 2021 | Clippers | 78 | Rockets | 103 |
| February | 2, 2021 | Rockets | 90 | Warriors | 120 |
| February | 5, 2021 | Rockets | 114 | Magic | 108 |
| February | 6, 2021 | Rockets | 108 | Raptors | 105 |
| February | 13, 2021 | Pistons | 91 | Rockets | 94 |
| February | 16, 2021 | Wizards | 89 | Rockets | 100 |
| February | 19, 2021 | Rockets | 88 | Mavericks | 106 |
| February | 21, 2021 | Rockets | 92 | Grizzlies | 94 |
| February | 23, 2021 | Knicks | 76 | Rockets | 103 |
| February | 25, 2021 | Nets | 80 | Rockets | 115 |
| February | 27, 2021 | Spurs | 109 | Rockets | 114 |
| March | 2, 2021 | Rockets | 121 | Clippers | 95 |
| March | 3, 2021 | Trailblazers | 101 | Rockets | 151 |
| March | 6, 2021 | Rockets | 98 | Heat | 90 |
| March | 9, 2021 | Rockets | 97 | Hawks | 92 |
| March | 11, 2021 | Jazz | 103 | Rockets | 114 |
| March | 13, 2021 | Rockets | 109 | Wolves | 114 |
| March | 15, 2021 | Thunder | 96 | Rockets | 125 |
| March | 17, 2021 | Cavaliers | 138 | Rockets | 142 |
| March | 18, 2021 | Rockets | 93 | Nuggets | 110 |
| March | 21, 2021 | Kings | 89 | Rockets | 91 |
| March | 24, 2021 | Warriors | 102 | Rockets | 106 |
| March | 27, 2021 | Rockets | 98 | Lakers | 109 |
| March | 30, 2021 | 76ers | 74 | Rockets | 104 |
| April | 1, 2021 | Rockets | 92 | Pelicans | 103 |
| April | 2, 2021 | Lakers | 108 | Rockets | 121 |
| April | 4, 2021 | Bulls | 82 | Rockets | 108 |
| April | 7, 2021 | Rockets | 81 | Kings | 87 |
| April | 9, 2021 | Suns | 90 | Rockets | 116 |
| April | 12, 2021 | Mavericks | 107 | Rockets | 96 |
| April | 15, 2021 | Wolves | 105 | Rockets | 128 |
| April | 18, 2021 | Rockets | 113 | Thunder | 98 |
| April | 20, 2021 | Jazz | 74 | Rockets | 106 |
| April | 22, 2021 | Pelicans | 98 | Rockets | 109 |
| April | 23, 2021 | Rockets | 81 | Grizzlies | 94 |
| April | 25, 2021 | Trailblazers | 97 | Rockets | 131 |
| April | 28, 2021 | Rockets | 72 | Suns | 97 |
| May | 1, 2021 | Rockets | 84 | Jazz | 93 |
| Post | 1, 2021 | Grizzlies | 109 | Rockets | 92 |
| Post | 2, 2021 | Grizzlies | 87 | Rockets | 91 |
| Post | 3, 2021 | Rockets | 70 | Grizzlies | 103 |
| Post | 4, 2021 | Rockets | 99 | Grizzlies | 93 |
| Post | 5, 2021 | Grizzlies | 78 | Rockets | 102 |
| Post | 6, 2021 | Rockets | 95 | Grizzlies | 100 |
| Post | 7, 2021 | Grizzlies | 81 | Rockets | 92 |
| Post | 8, 2021 | Mavericks | 90 | Rockets | 72 |
| Post | 9, 2021 | Mavericks | 97 | Rockets | 71 |
| Post | 10, 2021 | Rockets | 90 | Mavericks | 96 |
| Post | 11, 2021 | Rockets | 100 | Mavericks | 90 |
| Post | 12, 2021 | Mavericks | 96 | Rockets | 95 |
| Post | 13, 2021 | Rockets | | Mavericks | |
| Post | 14, 2021 | Mavericks | | Rockets | |