| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Nets | 96 | Pistons | 101 |
| November | 5, 2020 | Pistons | 103 | Bucks | 102 |
| November | 7, 2020 | Hawks | 112 | Pistons | 130 |
| November | 8, 2020 | Mavericks | 112 | Pistons | 125 |
| November | 11, 2020 | Celtics | 105 | Pistons | 145 |
| November | 12, 2020 | 76ers | 120 | Pistons | 133 |
| November | 15, 2020 | Pelicans | 111 | Pistons | 106 |
| November | 16, 2020 | Magic | 144 | Pistons | 148 |
| November | 17, 2020 | Pistons | 108 | Jazz | 104 |
| November | 19, 2020 | Pistons | 119 | Raptors | 101 |
| November | 21, 2020 | Grizzlies | 117 | Pistons | 120 |
| November | 23, 2020 | Pistons | 113 | Hawks | 102 |
| November | 26, 2020 | Pistons | 120 | Knicks | 92 |
| November | 28, 2020 | Suns | 115 | Pistons | 102 |
| December | 1, 2020 | Pistons | 113 | Thunder | 134 |
| December | 2, 2020 | Wizards | 104 | Pistons | 122 |
| December | 5, 2020 | Pistons | 99 | Pacers | 116 |
| December | 6, 2020 | Warriors | 106 | Pistons | 96 |
| December | 7, 2020 | Pistons | 101 | Lakers | 106 |
| December | 10, 2020 | Raptors | 106 | Pistons | 128 |
| December | 12, 2020 | Pistons | 100 | Hornets | 113 |
| December | 15, 2020 | Bucks | 108 | Pistons | 134 |
| December | 16, 2020 | Pistons | 134 | Spurs | 138 |
| December | 19, 2020 | Pistons | 115 | Bulls | 73 |
| December | 22, 2020 | Nets | 103 | Pistons | 116 |
| December | 26, 2020 | Pacers | 78 | Pistons | 111 |
| December | 27, 2020 | Kings | 86 | Pistons | 85 |
| December | 29, 2020 | Rockets | 88 | Pistons | 112 |
| December | 30, 2020 | Bulls | 110 | Pistons | 131 |
| January | 2, 2021 | Bucks | 93 | Pistons | 99 |
| January | 3, 2021 | Pistons | 125 | Grizzlies | 104 |
| January | 5, 2021 | Pistons | 122 | Heat | 128 |
| January | 6, 2021 | Wolves | 98 | Pistons | 138 |
| January | 8, 2021 | Hawks | 103 | Pistons | 101 |
| January | 10, 2021 | Hornets | 80 | Pistons | 106 |
| January | 12, 2021 | Pistons | 146 | Cavaliers | 117 |
| January | 14, 2021 | Pistons | 115 | Wizards | 116 |
| January | 15, 2021 | Pistons | 102 | Kings | 93 |
| January | 18, 2021 | Trailblazers | 111 | Pistons | 131 |
| January | 20, 2021 | Clippers | 124 | Pistons | 126 |
| January | 23, 2021 | Pistons | 128 | Raptors | 127 |
| January | 26, 2021 | Pistons | 93 | Bucks | 91 |
| January | 29, 2021 | Pistons | 119 | Pelicans | 111 |
| January | 30, 2021 | Bulls | 108 | Pistons | 109 |
| February | 2, 2021 | Raptors | 114 | Pistons | 119 |
| February | 6, 2021 | Wizards | 95 | Pistons | 120 |
| February | 7, 2021 | Magic | 110 | Pistons | 122 |
| February | 13, 2021 | Pistons | 91 | Rockets | 94 |
| February | 15, 2021 | Pistons | 106 | Nuggets | 116 |
| February | 18, 2021 | Lakers | 125 | Pistons | 103 |
| February | 20, 2021 | Pistons | 100 | Knicks | 75 |
| February | 22, 2021 | Heat | 104 | Pistons | 141 |
| February | 24, 2021 | Jazz | 104 | Pistons | 94 |
| February | 27, 2021 | Pistons | 128 | Nets | 104 |
| March | 1, 2021 | Pistons | 124 | 76ers | 111 |
| March | 2, 2021 | Pistons | 87 | Mavericks | 77 |
| March | 5, 2021 | Thunder | 92 | Pistons | 116 |
| March | 7, 2021 | Pistons | 123 | Wolves | 110 |
| March | 8, 2021 | Pistons | 129 | Magic | 97 |
| March | 11, 2021 | Pistons | 95 | Warriors | 102 |
| March | 14, 2021 | Spurs | 113 | Pistons | 119 |
| March | 17, 2021 | Pistons | 127 | Celtics | 119 |
| March | 18, 2021 | Pistons | 134 | Bulls | 115 |
| March | 21, 2021 | Hornets | 88 | Pistons | 97 |
| March | 24, 2021 | Pistons | 112 | Cavaliers | 94 |
| March | 25, 2021 | Pistons | 111 | 76ers | 98 |
| March | 28, 2021 | Pistons | 119 | Nets | 129 |
| March | 31, 2021 | Pistons | 94 | Magic | 129 |
| April | 5, 2021 | Pistons | 125 | Clippers | 101 |
| April | 7, 2021 | Knicks | 94 | Pistons | 113 |
| April | 8, 2021 | Pistons | 96 | Wizards | 114 |
| April | 11, 2021 | Pistons | 125 | Heat | 122 |
| April | 13, 2021 | Pistons | 116 | Pacers | 96 |
| April | 15, 2021 | Knicks | 117 | Pistons | 145 |
| April | 17, 2021 | Cavaliers | 117 | Pistons | 144 |
| April | 18, 2021 | Celtics | 92 | Pistons | 115 |
| April | 20, 2021 | Pistons | 121 | Suns | 114 |
| April | 21, 2021 | Heat | 100 | Pistons | 119 |
| April | 24, 2021 | Nuggets | 117 | Pistons | 127 |
| April | 27, 2021 | Pistons | 104 | Hornets | 74 |
| April | 30, 2021 | 76ers | 112 | Pistons | 122 |
| May | 1, 2021 | Pistons | 127 | Trailblazers | 114 |
| Post | 1, 2021 | Wizards | 79 | Pistons | 108 |
| Post | 2, 2021 | Wizards | 98 | Pistons | 108 |
| Post | 3, 2021 | Pistons | 126 | Wizards | 96 |
| Post | 4, 2021 | Pistons | 115 | Wizards | 94 |
| Post | 5, 2021 | Wizards | | Pistons | |
| Post | 6, 2021 | Pistons | | Wizards | |
| Post | 7, 2021 | Wizards | | Pistons | |
| Post | 8, 2021 | Hornets | 105 | Pistons | 110 |
| Post | 9, 2021 | Hornets | 97 | Pistons | 93 |
| Post | 10, 2021 | Pistons | 109 | Hornets | 106 |
| Post | 11, 2021 | Pistons | 94 | Hornets | 102 |
| Post | 12, 2021 | Hornets | 84 | Pistons | 90 |
| Post | 13, 2021 | Pistons | 96 | Hornets | 92 |
| Post | 14, 2021 | Hornets | | Pistons | |
| Post | 15, 2021 | Raptors | 94 | Pistons | 87 |
| Post | 16, 2021 | Raptors | 107 | Pistons | 93 |
| Post | 17, 2021 | Pistons | 108 | Raptors | 104 |
| Post | 18, 2021 | Pistons | 99 | Raptors | 88 |
| Post | 19, 2021 | Raptors | 92 | Pistons | 112 |
| Post | 20, 2021 | Pistons | 113 | Raptors | 101 |
| Post | 21, 2021 | Raptors | | Pistons | |
| Post | 22, 2021 | Kings | 78 | Pistons | 87 |
| Post | 23, 2021 | Kings | 95 | Pistons | 93 |
| Post | 24, 2021 | Pistons | 82 | Kings | 94 |
| Post | 25, 2021 | Pistons | 86 | Kings | 88 |
| Post | 26, 2021 | Pistons | 80 | Kings | 84 |