| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Heat | 83 | Cavaliers | 117 |
| November | 4, 2020 | Cavaliers | 108 | Wolves | 99 |
| November | 6, 2020 | Cavaliers | 104 | Hornets | 113 |
| November | 8, 2020 | Trailblazers | 128 | Cavaliers | 114 |
| November | 10, 2020 | Cavaliers | 100 | Bucks | 116 |
| November | 12, 2020 | Cavaliers | 106 | Kings | 113 |
| November | 13, 2020 | Magic | 125 | Cavaliers | 118 |
| November | 15, 2020 | Warriors | 119 | Cavaliers | 105 |
| November | 16, 2020 | Cavaliers | 95 | 76ers | 116 |
| November | 18, 2020 | Cavaliers | 108 | Knicks | 103 |
| November | 20, 2020 | Bucks | 119 | Cavaliers | 131 |
| November | 22, 2020 | Cavaliers | 113 | Raptors | 107 |
| November | 25, 2020 | Thunder | 117 | Cavaliers | 123 |
| November | 26, 2020 | Wizards | 112 | Cavaliers | 123 |
| November | 28, 2020 | Cavaliers | 108 | Nets | 103 |
| November | 30, 2020 | Suns | 118 | Cavaliers | 115 |
| December | 2, 2020 | Cavaliers | 83 | Hornets | 105 |
| December | 5, 2020 | Celtics | 111 | Cavaliers | 116 |
| December | 8, 2020 | Magic | 110 | Cavaliers | 104 |
| December | 10, 2020 | Cavaliers | 133 | Clippers | 113 |
| December | 13, 2020 | Cavaliers | 117 | Heat | 104 |
| December | 15, 2020 | Jazz | 123 | Cavaliers | 107 |
| December | 17, 2020 | Grizzlies | 126 | Cavaliers | 115 |
| December | 20, 2020 | Cavaliers | 102 | Lakers | 132 |
| December | 21, 2020 | Rockets | 110 | Cavaliers | 105 |
| December | 25, 2020 | Cavaliers | 99 | Mavericks | 124 |
| December | 26, 2020 | Cavaliers | 116 | Pelicans | 110 |
| December | 28, 2020 | Pacers | 133 | Cavaliers | 114 |
| December | 30, 2020 | Hawks | 84 | Cavaliers | 106 |
| January | 2, 2021 | Cavaliers | 115 | Spurs | 133 |
| January | 4, 2021 | Cavaliers | 129 | Bulls | 125 |
| January | 6, 2021 | Kings | 101 | Cavaliers | 122 |
| January | 9, 2021 | Cavaliers | 102 | Celtics | 117 |
| January | 12, 2021 | Pistons | 146 | Cavaliers | 117 |
| January | 15, 2021 | Cavaliers | 107 | Hawks | 126 |
| January | 18, 2021 | Hornets | 104 | Cavaliers | 92 |
| January | 21, 2021 | Wolves | 111 | Cavaliers | 128 |
| January | 23, 2021 | Cavaliers | 107 | Grizzlies | 95 |
| January | 25, 2021 | Nuggets | 106 | Cavaliers | 115 |
| January | 26, 2021 | Pelicans | 118 | Cavaliers | 89 |
| January | 29, 2021 | 76ers | 119 | Cavaliers | 104 |
| February | 1, 2021 | Cavaliers | 122 | Hawks | 124 |
| February | 4, 2021 | Mavericks | 112 | Cavaliers | 118 |
| February | 6, 2021 | Cavaliers | 99 | Heat | 123 |
| February | 14, 2021 | Cavaliers | 106 | Bulls | 112 |
| February | 17, 2021 | Lakers | 104 | Cavaliers | 114 |
| February | 20, 2021 | Raptors | 110 | Cavaliers | 125 |
| February | 23, 2021 | Raptors | 131 | Cavaliers | 74 |
| February | 26, 2021 | Cavaliers | 105 | Wizards | 113 |
| March | 1, 2021 | Knicks | 108 | Cavaliers | 144 |
| March | 2, 2021 | Cavaliers | 124 | Nuggets | 121 |
| March | 4, 2021 | Cavaliers | 115 | Jazz | 109 |
| March | 7, 2021 | Bucks | 100 | Cavaliers | 114 |
| March | 9, 2021 | Hornets | 86 | Cavaliers | 126 |
| March | 11, 2021 | Cavaliers | 112 | Wizards | 108 |
| March | 12, 2021 | 76ers | 110 | Cavaliers | 109 |
| March | 14, 2021 | Cavaliers | 125 | Warriors | 122 |
| March | 15, 2021 | Clippers | 122 | Cavaliers | 131 |
| March | 17, 2021 | Cavaliers | 138 | Rockets | 142 |
| March | 18, 2021 | Celtics | 114 | Cavaliers | 119 |
| March | 21, 2021 | Cavaliers | 124 | Trailblazers | 110 |
| March | 24, 2021 | Pistons | 112 | Cavaliers | 94 |
| March | 26, 2021 | Cavaliers | 108 | Nets | 83 |
| March | 27, 2021 | Cavaliers | 127 | Thunder | 89 |
| March | 29, 2021 | Cavaliers | 123 | Knicks | 102 |
| March | 30, 2021 | Pacers | 111 | Cavaliers | 115 |
| April | 2, 2021 | Spurs | 123 | Cavaliers | 118 |
| April | 4, 2021 | Cavaliers | 101 | Pacers | 112 |
| April | 6, 2021 | Nets | 110 | Cavaliers | 124 |
| April | 9, 2021 | Nets | 131 | Cavaliers | 120 |
| April | 11, 2021 | Cavaliers | 103 | Suns | 125 |
| April | 14, 2021 | Heat | 131 | Cavaliers | 112 |
| April | 16, 2021 | Bulls | 118 | Cavaliers | 108 |
| April | 17, 2021 | Cavaliers | 117 | Pistons | 144 |
| April | 19, 2021 | Cavaliers | 112 | 76ers | 113 |
| April | 21, 2021 | Cavaliers | 118 | Magic | 113 |
| April | 22, 2021 | Wizards | 111 | Cavaliers | 110 |
| April | 25, 2021 | Hawks | 116 | Cavaliers | 119 |
| April | 27, 2021 | Cavaliers | 100 | Raptors | 111 |
| April | 28, 2021 | Cavaliers | 103 | Celtics | 110 |
| April | 30, 2021 | Cavaliers | 88 | Bucks | 108 |
| May | 1, 2021 | Cavaliers | 102 | Magic | 125 |