| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Rockets | 83 | Spurs | 109 |
| November | 5, 2010 | Spurs | 113 | Pelicans | 107 |
| November | 7, 2010 | Pacers | 88 | Spurs | 95 |
| November | 9, 2010 | Wolves | 125 | Spurs | 114 |
| November | 12, 2010 | Spurs | 122 | Thunder | 109 |
| November | 14, 2010 | Spurs | 107 | Magic | 106 |
| November | 17, 2010 | Spurs | 117 | Bulls | 113 |
| November | 19, 2010 | Lakers | 102 | Spurs | 129 |
| November | 20, 2010 | Spurs | 120 | Clippers | 92 |
| November | 23, 2010 | Nets | 88 | Spurs | 107 |
| November | 25, 2010 | Spurs | 121 | Wolves | 86 |
| November | 27, 2010 | Trailblazers | 101 | Spurs | 102 |
| November | 30, 2010 | Spurs | 90 | Kings | 85 |
| December | 1, 2010 | Nuggets | 103 | Spurs | 133 |
| December | 4, 2010 | Spurs | 97 | 76ers | 80 |
| December | 7, 2010 | Spurs | 118 | Wizards | 120 |
| December | 9, 2010 | Spurs | 84 | Knicks | 104 |
| December | 12, 2010 | Spurs | 108 | Rockets | 126 |
| December | 14, 2010 | Suns | 78 | Spurs | 98 |
| December | 16, 2010 | Pistons | 106 | Spurs | 100 |
| December | 18, 2010 | Spurs | 92 | Warriors | 108 |
| December | 21, 2010 | Spurs | 107 | Mavericks | 124 |
| December | 25, 2010 | Spurs | 107 | Lakers | 103 |
| December | 26, 2010 | Spurs | 123 | Jazz | 97 |
| December | 28, 2010 | Bucks | 84 | Spurs | 87 |
| December | 31, 2010 | Spurs | 95 | Clippers | 105 |
| January | 2, 2011 | Cavaliers | 115 | Spurs | 119 |
| January | 5, 2011 | Spurs | 85 | Hawks | 86 |
| January | 8, 2011 | Grizzlies | 81 | Spurs | 95 |
| January | 10, 2011 | Spurs | 94 | Warriors | 109 |
| January | 11, 2011 | Rockets | 87 | Spurs | 91 |
| January | 13, 2011 | Spurs | 84 | Bucks | 100 |
| January | 15, 2011 | Spurs | 116 | Celtics | 104 |
| January | 17, 2011 | Jazz | 110 | Spurs | 120 |
| January | 18, 2011 | Spurs | 104 | Suns | 84 |
| January | 20, 2011 | Thunder | 110 | Spurs | 104 |
| January | 21, 2011 | Knicks | 84 | Spurs | 106 |
| January | 24, 2011 | Spurs | 114 | Lakers | 104 |
| January | 26, 2011 | Magic | 101 | Spurs | 113 |
| January | 29, 2011 | Suns | 101 | Spurs | 85 |
| February | 1, 2011 | Spurs | 112 | Trailblazers | 91 |
| February | 4, 2011 | 76ers | 111 | Spurs | 110 |
| February | 7, 2011 | Spurs | 125 | Wolves | 113 |
| February | 14, 2011 | Hawks | 87 | Spurs | 110 |
| February | 17, 2011 | Spurs | 78 | Kings | 92 |
| February | 19, 2011 | Pelicans | 98 | Spurs | 113 |
| February | 21, 2011 | Spurs | 99 | Heat | 98 |
| February | 24, 2011 | Spurs | 109 | Nets | 103 |
| February | 27, 2011 | Spurs | 132 | Rockets | 110 |
| March | 2, 2011 | Kings | 82 | Spurs | 64 |
| March | 4, 2011 | Spurs | 106 | Raptors | 104 |
| March | 5, 2011 | Celtics | 88 | Spurs | 113 |
| March | 7, 2011 | Spurs | 97 | Suns | 88 |
| March | 9, 2011 | Bulls | 110 | Spurs | 112 |
| March | 11, 2011 | Spurs | 106 | Nuggets | 102 |
| March | 12, 2011 | Grizzlies | 86 | Spurs | 94 |
| March | 14, 2011 | Spurs | 114 | Pistons | 102 |
| March | 15, 2011 | Lakers | 97 | Spurs | 137 |
| March | 18, 2011 | Thunder | 135 | Spurs | 130 |
| March | 20, 2011 | Wolves | 93 | Spurs | 128 |
| March | 23, 2011 | Spurs | 118 | Jazz | 107 |
| March | 24, 2011 | Raptors | 106 | Spurs | 115 |
| March | 26, 2011 | Wizards | 83 | Spurs | 98 |
| March | 27, 2011 | Spurs | 101 | Hornets | 113 |
| March | 29, 2011 | Pelicans | 100 | Spurs | 106 |
| March | 31, 2011 | Spurs | 101 | Pacers | 105 |
| April | 2, 2011 | Spurs | 102 | Cavaliers | 149 |
| April | 4, 2011 | Heat | 99 | Spurs | 108 |
| April | 6, 2011 | Trailblazers | 93 | Spurs | 117 |
| April | 9, 2011 | Clippers | 117 | Spurs | 115 |
| April | 10, 2011 | Nuggets | 100 | Spurs | 134 |
| April | 13, 2011 | Mavericks | 120 | Spurs | 125 |
| April | 16, 2011 | Spurs | 111 | Trailblazers | 97 |
| April | 18, 2011 | Warriors | 91 | Spurs | 102 |
| April | 19, 2011 | Hornets | 123 | Spurs | 111 |
| April | 21, 2011 | Spurs | 92 | Grizzlies | 105 |
| April | 22, 2011 | Jazz | 103 | Spurs | 117 |
| April | 24, 2011 | Kings | 97 | Spurs | 89 |
| April | 26, 2011 | Spurs | 112 | Pelicans | 115 |
| April | 29, 2011 | Spurs | 91 | Mavericks | 101 |
| April | 30, 2011 | Spurs | 106 | Grizzlies | 126 |
| May | 1, 2011 | Clippers | 82 | Spurs | 121 |
| Post | 1, 2011 | Mavericks | 93 | Spurs | 119 |
| Post | 2, 2011 | Mavericks | 114 | Spurs | 129 |
| Post | 3, 2011 | Spurs | 111 | Mavericks | 113 |
| Post | 4, 2011 | Spurs | 134 | Mavericks | 125 |
| Post | 5, 2011 | Mavericks | 118 | Spurs | 136 |
| Post | 6, 2011 | Spurs | | Mavericks | |
| Post | 7, 2011 | Mavericks | | Spurs | |
| Post | 8, 2011 | Kings | 91 | Spurs | 88 |
| Post | 9, 2011 | Kings | 99 | Spurs | 113 |
| Post | 10, 2011 | Spurs | 91 | Kings | 93 |
| Post | 11, 2011 | Spurs | 92 | Kings | 99 |
| Post | 12, 2011 | Kings | 84 | Spurs | 91 |
| Post | 13, 2011 | Spurs | 61 | Kings | 92 |
| Post | 14, 2011 | Kings | | Spurs | |