| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Rockets | 92 | Spurs | 108 |
| November | 3, 2010 | Rockets | 79 | Mavericks | 136 |
| November | 6, 2010 | Pelicans | 117 | Rockets | 115 |
| November | 8, 2010 | Thunder | 99 | Rockets | 66 |
| November | 11, 2010 | Rockets | 85 | Nuggets | 99 |
| November | 13, 2010 | Pacers | 103 | Rockets | 115 |
| November | 14, 2010 | Kings | 95 | Rockets | 81 |
| November | 17, 2010 | Rockets | 74 | Bucks | 115 |
| November | 19, 2010 | Rockets | 91 | Wizards | 109 |
| November | 22, 2010 | Rockets | 105 | Hornets | 102 |
| November | 24, 2010 | Rockets | 86 | Bulls | 93 |
| November | 26, 2010 | Rockets | 123 | Suns | 116 |
| November | 28, 2010 | Grizzlies | 79 | Rockets | 99 |
| November | 30, 2010 | Rockets | 88 | Pelicans | 130 |
| December | 1, 2010 | Rockets | 102 | Jazz | 106 |
| December | 3, 2010 | Rockets | 98 | Wolves | 107 |
| December | 6, 2010 | Hawks | 81 | Rockets | 80 |
| December | 8, 2010 | Clippers | 91 | Rockets | 99 |
| December | 9, 2010 | Celtics | 112 | Rockets | 116 |
| December | 11, 2010 | Rockets | 88 | Trailblazers | 94 |
| December | 12, 2010 | Spurs | 96 | Rockets | 98 |
| December | 14, 2010 | Nuggets | 112 | Rockets | 116 |
| December | 17, 2010 | Rockets | 114 | 76ers | 119 |
| December | 18, 2010 | Rockets | 104 | Knicks | 107 |
| December | 21, 2010 | Rockets | 106 | Cavaliers | 116 |
| December | 23, 2010 | Heat | 99 | Rockets | 109 |
| December | 26, 2010 | Suns | 103 | Rockets | 126 |
| December | 29, 2010 | Rockets | 122 | Pistons | 120 |
| December | 31, 2010 | Rockets | 103 | Pacers | 86 |
| January | 1, 2011 | Warriors | 139 | Rockets | 131 |
| January | 3, 2011 | Magic | 104 | Rockets | 124 |
| January | 6, 2011 | Rockets | 122 | Lakers | 111 |
| January | 8, 2011 | Rockets | 88 | Thunder | 105 |
| January | 11, 2011 | Rockets | 103 | Spurs | 97 |
| January | 13, 2011 | Nuggets | 113 | Rockets | 114 |
| January | 15, 2011 | Rockets | 125 | Nets | 97 |
| January | 16, 2011 | Rockets | 123 | Celtics | 113 |
| January | 18, 2011 | Rockets | 102 | Warriors | 108 |
| January | 20, 2011 | Mavericks | 119 | Rockets | 115 |
| January | 21, 2011 | Raptors | 128 | Rockets | 117 |
| January | 23, 2011 | Bucks | 108 | Rockets | 94 |
| January | 25, 2011 | Rockets | 94 | Trailblazers | 98 |
| January | 27, 2011 | Lakers | 107 | Rockets | 104 |
| January | 29, 2011 | Hornets | 87 | Rockets | 88 |
| January | 31, 2011 | Clippers | 94 | Rockets | 83 |
| February | 2, 2011 | Rockets | 107 | Warriors | 98 |
| February | 5, 2011 | Rockets | 112 | Magic | 109 |
| February | 6, 2011 | Rockets | 101 | Raptors | 117 |
| February | 13, 2011 | Pistons | 115 | Rockets | 133 |
| February | 16, 2011 | Wizards | 87 | Rockets | 103 |
| February | 19, 2011 | Rockets | 116 | Mavericks | 120 |
| February | 21, 2011 | Rockets | 91 | Grizzlies | 80 |
| February | 23, 2011 | Knicks | 116 | Rockets | 105 |
| February | 25, 2011 | Nets | 95 | Rockets | 108 |
| February | 27, 2011 | Spurs | 105 | Rockets | 100 |
| March | 2, 2011 | Rockets | 104 | Clippers | 100 |
| March | 3, 2011 | Trailblazers | 79 | Rockets | 97 |
| March | 6, 2011 | Rockets | 99 | Heat | 122 |
| March | 9, 2011 | Rockets | 87 | Hawks | 114 |
| March | 11, 2011 | Jazz | 137 | Rockets | 144 |
| March | 13, 2011 | Rockets | 122 | Wolves | 124 |
| March | 15, 2011 | Thunder | 113 | Rockets | 86 |
| March | 17, 2011 | Cavaliers | 127 | Rockets | 123 |
| March | 18, 2011 | Rockets | 79 | Nuggets | 114 |
| March | 21, 2011 | Kings | 91 | Rockets | 95 |
| March | 24, 2011 | Warriors | 101 | Rockets | 120 |
| March | 27, 2011 | Rockets | 125 | Lakers | 123 |
| March | 30, 2011 | 76ers | 115 | Rockets | 134 |
| April | 1, 2011 | Rockets | 107 | Pelicans | 106 |
| April | 2, 2011 | Lakers | 98 | Rockets | 108 |
| April | 4, 2011 | Bulls | 94 | Rockets | 106 |
| April | 7, 2011 | Rockets | 84 | Kings | 98 |
| April | 9, 2011 | Suns | 118 | Rockets | 114 |
| April | 12, 2011 | Mavericks | 111 | Rockets | 107 |
| April | 15, 2011 | Wolves | 107 | Rockets | 112 |
| April | 18, 2011 | Rockets | 134 | Thunder | 106 |
| April | 20, 2011 | Jazz | 107 | Rockets | 117 |
| April | 22, 2011 | Pelicans | 127 | Rockets | 122 |
| April | 23, 2011 | Rockets | 101 | Grizzlies | 77 |
| April | 25, 2011 | Trailblazers | 94 | Rockets | 112 |
| April | 28, 2011 | Rockets | 94 | Suns | 101 |
| May | 1, 2011 | Rockets | 101 | Jazz | 107 |