| month | day | visitor | score | home | score |
|---|
| November | 2, 2009 | Spurs | 83 | Suns | 113 |
| November | 3, 2009 | Jazz | 116 | Spurs | 78 |
| November | 4, 2009 | Spurs | 106 | Raptors | 126 |
| November | 6, 2009 | Nuggets | 113 | Spurs | 107 |
| November | 8, 2009 | Blazers | 105 | Spurs | 89 |
| November | 12, 2009 | Grizzlies | 87 | Spurs | 116 |
| November | 13, 2009 | Mavericks | 99 | Spurs | 90 |
| November | 15, 2009 | Hawks | 120 | Spurs | 79 |
| November | 16, 2009 | Spurs | 116 | Mavericks | 101 |
| November | 18, 2009 | Spurs | 106 | Nets | 122 |
| November | 19, 2009 | Cavaliers | 114 | Spurs | 98 |
| November | 21, 2009 | Clippers | 107 | Spurs | 113 |
| November | 23, 2009 | Spurs | 78 | Celtics | 110 |
| November | 29, 2009 | Clippers | 97 | Spurs | 85 |
| November | 30, 2009 | Pistons | 87 | Spurs | 114 |
| December | 1, 2009 | Spurs | 96 | Cavaliers | 127 |
| December | 2, 2009 | Warriors | 113 | Spurs | 91 |
| December | 4, 2009 | Heat | 122 | Spurs | 104 |
| December | 6, 2009 | Nets | 109 | Spurs | 97 |
| December | 10, 2009 | Spurs | 107 | Suns | 126 |
| December | 11, 2009 | Spurs | 96 | Hawks | 102 |
| December | 13, 2009 | Spurs | 99 | Nuggets | 127 |
| December | 16, 2009 | Mavericks | 94 | Spurs | 111 |
| December | 17, 2009 | Bulls | 110 | Spurs | 96 |
| December | 20, 2009 | Spurs | 112 | Kings | 120 |
| December | 22, 2009 | Raptors | 102 | Spurs | 101 |
| December | 23, 2009 | Spurs | 104 | Hornets | 117 |
| December | 24, 2009 | Rockets | 121 | Spurs | 112 |
| December | 28, 2009 | Spurs | 94 | Wolves | 101 |
| December | 29, 2009 | Thunder | 105 | Spurs | 93 |
| January | 1, 2010 | Spurs | 93 | Magic | 120 |
| January | 7, 2010 | 76ers | 128 | Spurs | 116 |
| January | 10, 2010 | Spurs | 105 | Kings | 120 |
| January | 12, 2010 | Spurs | 91 | Warriors | 108 |
| January | 13, 2010 | Spurs | 89 | Jazz | 101 |
| January | 15, 2010 | Kings | 115 | Spurs | 97 |
| January | 18, 2010 | Spurs | 104 | Wizards | 103 |
| January | 22, 2010 | Spurs | 108 | Lakers | 111 |
| January | 26, 2010 | Spurs | 106 | Blazers | 104 |
| January | 27, 2010 | Lakers | 108 | Spurs | 101 |
| February | 1, 2010 | Rockets | 104 | Spurs | 81 |
| February | 5, 2010 | Wizards | 105 | Spurs | 120 |
| February | 13, 2010 | Spurs | 93 | Thunder | 102 |
| February | 16, 2010 | Kings | 95 | Spurs | 122 |
| February | 18, 2010 | Spurs | 106 | Hornets | 118 |
| February | 22, 2010 | Spurs | 99 | Bucks | 101 |
| February | 23, 2010 | Spurs | 90 | Knicks | 111 |
| February | 24, 2010 | Spurs | 105 | Heat | 103 |
| February | 25, 2010 | Spurs | 99 | Clippers | 124 |
| February | 26, 2010 | Spurs | 106 | Clippers | 109 |
| March | 1, 2010 | Spurs | 98 | Blazers | 112 |
| March | 2, 2010 | Spurs | 78 | Bulls | 119 |
| March | 3, 2010 | Wolves | 96 | Spurs | 112 |
| March | 5, 2010 | Spurs | 72 | Grizzlies | 109 |
| March | 8, 2010 | Spurs | 112 | Pacers | 120 |
| March | 11, 2010 | Bobcats | 97 | Spurs | 95 |
| March | 13, 2010 | Magic | 109 | Spurs | 129 |
| March | 14, 2010 | Spurs | 79 | Jazz | 112 |
| March | 18, 2010 | Spurs | 93 | Rockets | 104 |
| March | 19, 2010 | Bucks | 88 | Spurs | 84 |
| March | 21, 2010 | Spurs | 114 | Thunder | 150 |
| March | 23, 2010 | Suns | 118 | Spurs | 111 |
| March | 27, 2010 | Spurs | 98 | 76ers | 138 |
| March | 30, 2010 | Jazz | 108 | Spurs | 106 |
| March | 31, 2010 | Suns | 106 | Spurs | 114 |
| April | 4, 2010 | Nuggets | 101 | Spurs | 103 |
| April | 7, 2010 | Celtics | 95 | Spurs | 105 |
| April | 8, 2010 | Spurs | 112 | Lakers | 137 |
| April | 9, 2010 | Spurs | 98 | Bobcats | 112 |
| April | 12, 2010 | Hornets | 120 | Spurs | 108 |
| April | 14, 2010 | Hornets | 95 | Spurs | 97 |
| April | 15, 2010 | Warriors | 113 | Spurs | 127 |
| April | 18, 2010 | Spurs | 95 | Mavericks | 102 |
| April | 19, 2010 | Spurs | 87 | Grizzlies | 103 |
| April | 22, 2010 | Spurs | 101 | Pistons | 114 |
| April | 25, 2010 | Spurs | 103 | Wolves | 120 |
| April | 26, 2010 | Knicks | 102 | Spurs | 99 |
| April | 28, 2010 | Pacers | 94 | Spurs | 140 |
| April | 29, 2010 | Thunder | 129 | Spurs | 100 |
| May | 1, 2010 | Lakers | 101 | Spurs | 96 |
| May | 2, 2010 | Grizzlies | 89 | Spurs | 102 |
| May | 3, 2010 | Spurs | 90 | Warriors | 114 |