| month | day | visitor | score | home | score |
|---|
| November | 3, 2009 | Nets | 82 | Pistons | 83 |
| November | 5, 2009 | Pistons | 74 | Warriors | 104 |
| November | 13, 2009 | 76ers | 116 | Pistons | 103 |
| November | 14, 2009 | Suns | 110 | Pistons | 100 |
| November | 15, 2009 | Blazers | 106 | Pistons | 85 |
| November | 17, 2009 | Lakers | 119 | Pistons | 99 |
| November | 20, 2009 | Kings | 94 | Pistons | 71 |
| November | 21, 2009 | Hornets | 87 | Pistons | 95 |
| November | 22, 2009 | Pacers | 79 | Pistons | 118 |
| November | 23, 2009 | Magic | 116 | Pistons | 95 |
| November | 26, 2009 | Pistons | 60 | Celtics | 103 |
| November | 28, 2009 | Bucks | 83 | Pistons | 77 |
| November | 30, 2009 | Pistons | 87 | Spurs | 114 |
| December | 5, 2009 | Clippers | 88 | Pistons | 71 |
| December | 7, 2009 | Pistons | 66 | Knicks | 94 |
| December | 8, 2009 | Pistons | 80 | Rockets | 97 |
| December | 9, 2009 | Bucks | 96 | Pistons | 97 |
| December | 10, 2009 | Pistons | 93 | Wolves | 99 |
| December | 12, 2009 | Pistons | 100 | Raptors | 101 |
| December | 15, 2009 | Pistons | 71 | Heat | 93 |
| December | 16, 2009 | Pistons | 101 | Celtics | 123 |
| December | 17, 2009 | Pistons | 98 | Heat | 96 |
| December | 18, 2009 | Pistons | 85 | Nets | 101 |
| December | 21, 2009 | Hawks | 110 | Pistons | 84 |
| December | 22, 2009 | Pistons | 93 | Suns | 96 |
| December | 23, 2009 | Magic | 128 | Pistons | 96 |
| December | 25, 2009 | Pistons | 106 | Hornets | 108 |
| December | 26, 2009 | 76ers | 109 | Pistons | 108 |
| December | 29, 2009 | Pistons | 95 | Bulls | 125 |
| January | 1, 2010 | Pistons | 78 | Knicks | 82 |
| January | 4, 2010 | Pistons | 81 | Bobcats | 110 |
| January | 5, 2010 | Pistons | 78 | Hawks | 112 |
| January | 6, 2010 | Pistons | 89 | Bulls | 111 |
| January | 12, 2010 | Pistons | 70 | Bucks | 102 |
| January | 14, 2010 | Mavericks | 99 | Pistons | 96 |
| January | 15, 2010 | Bulls | 120 | Pistons | 96 |
| January | 16, 2010 | Bulls | 111 | Pistons | 92 |
| January | 17, 2010 | Cavaliers | 123 | Pistons | 112 |
| January | 22, 2010 | Pistons | 120 | 76ers | 114 |
| January | 23, 2010 | Bobcats | 91 | Pistons | 77 |
| January | 25, 2010 | Pacers | 103 | Pistons | 120 |
| January | 26, 2010 | Grizzlies | 92 | Pistons | 76 |
| January | 27, 2010 | Pistons | 79 | Wizards | 89 |
| January | 30, 2010 | Celtics | 102 | Pistons | 76 |
| January | 31, 2010 | Heat | 103 | Pistons | 79 |
| February | 7, 2010 | Cavaliers | 105 | Pistons | 98 |
| February | 12, 2010 | Pistons | 113 | Blazers | 116 |
| February | 18, 2010 | Rockets | 118 | Pistons | 94 |
| February | 20, 2010 | Knicks | 105 | Pistons | 98 |
| February | 22, 2010 | Pistons | 87 | Magic | 117 |
| February | 23, 2010 | Thunder | 104 | Pistons | 91 |
| February | 24, 2010 | Warriors | 93 | Pistons | 92 |
| March | 1, 2010 | Wizards | 88 | Pistons | 103 |
| March | 5, 2010 | Wolves | 97 | Pistons | 103 |
| March | 7, 2010 | Knicks | 85 | Pistons | 96 |
| March | 9, 2010 | Raptors | 107 | Pistons | 82 |
| March | 12, 2010 | Pistons | 81 | Raptors | 95 |
| March | 16, 2010 | Hawks | 96 | Pistons | 100 |
| March | 19, 2010 | Pistons | 98 | Pacers | 107 |
| March | 21, 2010 | Celtics | 127 | Pistons | 101 |
| March | 23, 2010 | Pistons | 84 | Bucks | 89 |
| March | 24, 2010 | Pistons | 98 | Mavericks | 92 |
| March | 28, 2010 | Pistons | 97 | Thunder | 133 |
| April | 1, 2010 | Heat | 104 | Pistons | 70 |
| April | 3, 2010 | Pistons | 113 | Cavaliers | 122 |
| April | 4, 2010 | Pistons | 100 | Cavaliers | 116 |
| April | 6, 2010 | Pistons | 94 | Grizzlies | 90 |
| April | 7, 2010 | Nets | 84 | Pistons | 89 |
| April | 9, 2010 | Nuggets | 97 | Pistons | 93 |
| April | 10, 2010 | Pistons | 76 | Nets | 110 |
| April | 12, 2010 | Pistons | 98 | Bobcats | 110 |
| April | 17, 2010 | Pistons | 101 | Nuggets | 98 |
| April | 21, 2010 | Pistons | 86 | Clippers | 100 |
| April | 22, 2010 | Spurs | 101 | Pistons | 114 |
| April | 24, 2010 | Pistons | 90 | Magic | 109 |
| April | 25, 2010 | Wizards | 93 | Pistons | 76 |
| April | 26, 2010 | Pistons | 97 | Lakers | 104 |
| April | 28, 2010 | Pistons | 91 | Kings | 93 |
| April | 29, 2010 | Pistons | 92 | Wizards | 85 |
| April | 30, 2010 | Pistons | 96 | 76ers | 119 |
| May | 1, 2010 | Jazz | 104 | Pistons | 110 |
| May | 2, 2010 | Pistons | 102 | Jazz | 117 |