| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Pistons | 106 | Bucks | 114 |
| November | 3, 2010 | Pistons | 98 | Spurs | 115 |
| November | 5, 2010 | Warriors | 87 | Pistons | 78 |
| November | 6, 2010 | Wizards | 103 | Pistons | 122 |
| November | 8, 2010 | Wolves | 99 | Pistons | 111 |
| November | 9, 2010 | Pacers | 119 | Pistons | 118 |
| November | 11, 2010 | Pistons | 97 | Nets | 114 |
| November | 12, 2010 | 76ers | 106 | Pistons | 98 |
| November | 15, 2010 | Pistons | 113 | Raptors | 93 |
| November | 17, 2010 | Heat | 75 | Pistons | 108 |
| November | 21, 2010 | Pistons | 101 | Nuggets | 117 |
| November | 24, 2010 | Wizards | 88 | Pistons | 108 |
| November | 26, 2010 | Pistons | 124 | Rockets | 121 |
| November | 28, 2010 | Celtics | 110 | Pistons | 97 |
| November | 30, 2010 | Heat | 103 | Pistons | 94 |
| December | 3, 2010 | Pistons | 94 | Heat | 109 |
| December | 4, 2010 | Raptors | 101 | Pistons | 127 |
| December | 7, 2010 | Pistons | 101 | Bulls | 91 |
| December | 8, 2010 | Pistons | 131 | Kings | 120 |
| December | 12, 2010 | Bucks | 119 | Pistons | 121 |
| December | 15, 2010 | Spurs | 98 | Pistons | 101 |
| December | 17, 2010 | Nets | 111 | Pistons | 131 |
| December | 19, 2010 | Pistons | 87 | Trailblazers | 78 |
| December | 20, 2010 | Pistons | 103 | Bulls | 100 |
| December | 22, 2010 | Pistons | 97 | Hornets | 104 |
| December | 27, 2010 | Pistons | 134 | Bucks | 114 |
| December | 28, 2010 | Pistons | 103 | 76ers | 114 |
| December | 31, 2010 | Pistons | 81 | Celtics | 110 |
| January | 2, 2011 | Nets | 112 | Pistons | 115 |
| January | 3, 2011 | Pistons | 103 | Cavaliers | 125 |
| January | 5, 2011 | Pistons | 104 | Magic | 128 |
| January | 6, 2011 | Pistons | 102 | Thunder | 81 |
| January | 8, 2011 | Pistons | 123 | Wizards | 93 |
| January | 10, 2011 | Pistons | 91 | Knicks | 111 |
| January | 11, 2011 | Grizzlies | 117 | Pistons | 112 |
| January | 14, 2011 | Mavericks | 108 | Pistons | 101 |
| January | 16, 2011 | Clippers | 95 | Pistons | 99 |
| January | 17, 2011 | Magic | 102 | Pistons | 92 |
| January | 19, 2011 | Lakers | 102 | Pistons | 123 |
| January | 23, 2011 | Hawks | 99 | Pistons | 124 |
| January | 27, 2011 | Suns | 97 | Pistons | 87 |
| January | 29, 2011 | Bucks | 104 | Pistons | 120 |
| January | 31, 2011 | Pistons | 109 | 76ers | 120 |
| February | 2, 2011 | Pelicans | 99 | Pistons | 104 |
| February | 6, 2011 | Knicks | 96 | Pistons | 92 |
| February | 11, 2011 | Pistons | 110 | Hawks | 95 |
| February | 12, 2011 | Pistons | 119 | Raptors | 108 |
| February | 14, 2011 | Trailblazers | 106 | Pistons | 115 |
| February | 18, 2011 | Bulls | 132 | Pistons | 118 |
| February | 22, 2011 | Pistons | 94 | Knicks | 118 |
| February | 25, 2011 | Pistons | 106 | Wolves | 121 |
| February | 26, 2011 | Pistons | 139 | Magic | 112 |
| March | 3, 2011 | Hawks | 115 | Pistons | 126 |
| March | 4, 2011 | Pistons | 108 | Celtics | 91 |
| March | 9, 2011 | Pistons | 125 | Jazz | 129 |
| March | 11, 2011 | Kings | 112 | Pistons | 99 |
| March | 13, 2011 | Knicks | 114 | Pistons | 103 |
| March | 14, 2011 | 76ers | 114 | Pistons | 110 |
| March | 16, 2011 | Pistons | 100 | Hornets | 122 |
| March | 17, 2011 | Pistons | 102 | Nets | 110 |
| March | 20, 2011 | Cavaliers | 134 | Pistons | 105 |
| March | 21, 2011 | Pistons | 121 | Mavericks | 135 |
| March | 24, 2011 | Thunder | 109 | Pistons | 104 |
| March | 26, 2011 | Hornets | 135 | Pistons | 103 |
| March | 28, 2011 | Jazz | 116 | Pistons | 121 |
| March | 30, 2011 | Cavaliers | 131 | Pistons | 142 |
| April | 1, 2011 | Bulls | 98 | Pistons | 107 |
| April | 2, 2011 | Pacers | 100 | Pistons | 119 |
| April | 5, 2011 | Pistons | 107 | Wizards | 109 |
| April | 6, 2011 | Pistons | 101 | Suns | 113 |
| April | 10, 2011 | Pistons | 116 | Lakers | 98 |
| April | 14, 2011 | Pistons | 116 | Grizzlies | 113 |
| April | 16, 2011 | Pistons | 113 | Heat | 116 |
| April | 17, 2011 | Pistons | 111 | Pelicans | 97 |
| April | 20, 2011 | Magic | 118 | Pistons | 120 |
| April | 21, 2011 | Pistons | 116 | Clippers | 94 |
| April | 24, 2011 | Pistons | 99 | Pacers | 104 |
| April | 25, 2011 | Nuggets | 82 | Pistons | 109 |
| April | 27, 2011 | Rockets | 118 | Pistons | 130 |
| April | 28, 2011 | Pistons | 125 | Warriors | 107 |
| April | 30, 2011 | Pistons | 114 | Cavaliers | 130 |
| May | 1, 2011 | Celtics | 99 | Pistons | 127 |