| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Lakers | 116 | Heat | 106 |
| November | 4, 2010 | Lakers | 96 | Magic | 113 |
| November | 7, 2010 | Pelicans | 118 | Lakers | 100 |
| November | 9, 2010 | Lakers | 93 | Grizzlies | 98 |
| November | 10, 2010 | Wizards | 115 | Lakers | 107 |
| November | 12, 2010 | Hornets | 139 | Lakers | 94 |
| November | 16, 2010 | Lakers | 88 | Warriors | 117 |
| November | 17, 2010 | Lakers | 124 | Clippers | 115 |
| November | 19, 2010 | Lakers | 100 | Kings | 103 |
| November | 20, 2010 | Lakers | 78 | Nuggets | 98 |
| November | 23, 2010 | Lakers | 106 | Bulls | 109 |
| November | 25, 2010 | Lakers | 93 | Jazz | 115 |
| November | 27, 2010 | Jazz | 127 | Lakers | 119 |
| November | 28, 2010 | Nets | 124 | Lakers | 128 |
| November | 30, 2010 | Magic | 116 | Lakers | 117 |
| December | 4, 2010 | Lakers | 94 | Grizzlies | 106 |
| December | 7, 2010 | Rockets | 104 | Lakers | 123 |
| December | 9, 2010 | Mavericks | 113 | Lakers | 125 |
| December | 10, 2010 | Suns | 120 | Lakers | 110 |
| December | 13, 2010 | Raptors | 107 | Lakers | 129 |
| December | 15, 2010 | Heat | 102 | Lakers | 119 |
| December | 17, 2010 | Lakers | 110 | Wolves | 118 |
| December | 19, 2010 | Pelicans | 100 | Lakers | 109 |
| December | 21, 2010 | Spurs | 98 | Lakers | 121 |
| December | 26, 2010 | Trailblazers | 108 | Lakers | 115 |
| December | 29, 2010 | Warriors | 102 | Lakers | 101 |
| December | 31, 2010 | Grizzlies | 102 | Lakers | 116 |
| January | 2, 2011 | 76ers | 98 | Lakers | 124 |
| January | 3, 2011 | Knicks | 121 | Lakers | 112 |
| January | 5, 2011 | Nuggets | 88 | Lakers | 109 |
| January | 8, 2011 | Lakers | 103 | Cavaliers | 109 |
| January | 10, 2011 | Lakers | 88 | Bucks | 101 |
| January | 12, 2011 | Celtics | 121 | Lakers | 119 |
| January | 16, 2011 | Grizzlies | 95 | Lakers | 106 |
| January | 17, 2011 | Trailblazers | 112 | Lakers | 114 |
| January | 19, 2011 | Lakers | 102 | Pistons | 123 |
| January | 21, 2011 | Jazz | 114 | Lakers | 110 |
| January | 22, 2011 | Lakers | 106 | Rockets | 112 |
| January | 24, 2011 | Thunder | 106 | Lakers | 101 |
| January | 26, 2011 | Lakers | 109 | Jazz | 114 |
| January | 28, 2011 | Lakers | 108 | Trailblazers | 110 |
| January | 30, 2011 | Lakers | 117 | Rockets | 109 |
| February | 1, 2011 | Lakers | 103 | Spurs | 114 |
| February | 2, 2011 | Mavericks | 118 | Lakers | 124 |
| February | 4, 2011 | Lakers | 118 | Suns | 119 |
| February | 11, 2011 | Spurs | 113 | Lakers | 106 |
| February | 12, 2011 | Nuggets | 101 | Lakers | 107 |
| February | 14, 2011 | Lakers | 78 | Knicks | 113 |
| February | 15, 2011 | Cavaliers | 130 | Lakers | 101 |
| February | 16, 2011 | Lakers | 96 | Nets | 117 |
| February | 19, 2011 | Lakers | 74 | Thunder | 98 |
| February | 22, 2011 | Lakers | 85 | Trailblazers | 107 |
| February | 23, 2011 | Lakers | 66 | Warriors | 87 |
| February | 24, 2011 | Lakers | 103 | Hornets | 85 |
| February | 28, 2011 | Warriors | 90 | Lakers | 89 |
| March | 1, 2011 | Lakers | 90 | Thunder | 119 |
| March | 5, 2011 | Lakers | 108 | Hawks | 129 |
| March | 8, 2011 | Lakers | 103 | 76ers | 118 |
| March | 10, 2011 | Lakers | 116 | Pacers | 107 |
| March | 11, 2011 | Clippers | 118 | Lakers | 114 |
| March | 14, 2011 | Pacers | 118 | Lakers | 132 |
| March | 15, 2011 | Lakers | 92 | Celtics | 125 |
| March | 18, 2011 | Lakers | 101 | Pelicans | 111 |
| March | 19, 2011 | Wolves | 97 | Lakers | 127 |
| March | 21, 2011 | Clippers | 107 | Lakers | 123 |
| March | 22, 2011 | Hawks | 116 | Lakers | 100 |
| March | 24, 2011 | Bucks | 97 | Lakers | 111 |
| March | 28, 2011 | Lakers | 104 | Wizards | 100 |
| March | 31, 2011 | Lakers | 121 | Raptors | 125 |
| April | 2, 2011 | Lakers | 98 | Suns | 108 |
| April | 6, 2011 | Lakers | 86 | Nuggets | 92 |
| April | 7, 2011 | Lakers | 87 | Wolves | 115 |
| April | 9, 2011 | Lakers | 111 | Mavericks | 102 |
| April | 10, 2011 | Pistons | 116 | Lakers | 98 |
| April | 12, 2011 | Lakers | 78 | Pelicans | 122 |
| April | 15, 2011 | Wolves | 98 | Lakers | 122 |
| April | 16, 2011 | Kings | 108 | Lakers | 102 |
| April | 20, 2011 | Lakers | 93 | Mavericks | 118 |
| April | 21, 2011 | Lakers | 107 | Spurs | 111 |
| April | 25, 2011 | Rockets | 109 | Lakers | 112 |
| April | 28, 2011 | Kings | 118 | Lakers | 96 |
| May | 1, 2011 | Bulls | 110 | Lakers | 115 |