| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Kings | 113 | Rockets | 93 |
| November | 3, 2010 | Raptors | 107 | Rockets | 116 |
| November | 10, 2010 | Rockets | 104 | Cavaliers | 98 |
| November | 13, 2010 | Nets | 116 | Rockets | 100 |
| November | 15, 2010 | Grizzlies | 88 | Rockets | 96 |
| November | 16, 2010 | Rockets | 104 | Hornets | 128 |
| November | 19, 2010 | Cavaliers | 107 | Rockets | 117 |
| November | 20, 2010 | Pistons | 95 | Rockets | 120 |
| November | 22, 2010 | Jazz | 82 | Rockets | 86 |
| November | 24, 2010 | Warriors | 88 | Rockets | 103 |
| November | 26, 2010 | Rockets | 99 | Pelicans | 112 |
| November | 28, 2010 | Grizzlies | 113 | Rockets | 106 |
| November | 29, 2010 | Rockets | 92 | Grizzlies | 101 |
| December | 2, 2010 | Spurs | 81 | Rockets | 99 |
| December | 4, 2010 | Rockets | 101 | Lakers | 94 |
| December | 6, 2010 | Bucks | 81 | Rockets | 93 |
| December | 12, 2010 | Thunder | 119 | Rockets | 125 |
| December | 13, 2010 | Heat | 88 | Rockets | 113 |
| December | 14, 2010 | Knicks | 71 | Rockets | 96 |
| December | 15, 2010 | Thunder | 105 | Rockets | 82 |
| December | 19, 2010 | Lakers | 118 | Rockets | 116 |
| December | 20, 2010 | Pacers | 103 | Rockets | 92 |
| December | 22, 2010 | Rockets | 95 | Suns | 100 |
| December | 26, 2010 | Mavericks | 110 | Rockets | 115 |
| December | 28, 2010 | Rockets | 97 | Magic | 99 |
| December | 29, 2010 | Rockets | 72 | Bucks | 87 |
| December | 31, 2010 | Nuggets | 105 | Rockets | 124 |
| January | 2, 2011 | Rockets | 98 | Clippers | 125 |
| January | 3, 2011 | Rockets | 112 | Spurs | 110 |
| January | 4, 2011 | Rockets | 103 | Kings | 120 |
| January | 5, 2011 | Rockets | 112 | 76ers | 129 |
| January | 6, 2011 | Rockets | 107 | Raptors | 89 |
| January | 11, 2011 | Rockets | 99 | Lakers | 111 |
| January | 12, 2011 | Bulls | 111 | Rockets | 117 |
| January | 15, 2011 | Rockets | 86 | Pelicans | 118 |
| January | 17, 2011 | Rockets | 93 | Jazz | 129 |
| January | 19, 2011 | Rockets | 73 | Suns | 109 |
| January | 20, 2011 | Rockets | 105 | Warriors | 107 |
| January | 21, 2011 | Rockets | 113 | Clippers | 107 |
| January | 22, 2011 | Rockets | 98 | Pistons | 121 |
| January | 23, 2011 | Lakers | 121 | Rockets | 133 |
| January | 25, 2011 | Pelicans | 105 | Rockets | 101 |
| January | 26, 2011 | Warriors | 107 | Rockets | 91 |
| February | 4, 2011 | Suns | 93 | Rockets | 92 |
| February | 11, 2011 | Rockets | 100 | Celtics | 110 |
| February | 14, 2011 | Clippers | 58 | Rockets | 83 |
| February | 15, 2011 | Celtics | 119 | Rockets | 109 |
| February | 22, 2011 | Rockets | 86 | Nets | 104 |
| February | 24, 2011 | Rockets | 84 | Spurs | 88 |
| February | 25, 2011 | Rockets | 67 | Pacers | 85 |
| February | 26, 2011 | Rockets | 103 | Heat | 75 |
| February | 27, 2011 | Nuggets | 92 | Rockets | 112 |
| March | 1, 2011 | Rockets | 83 | Knicks | 75 |
| March | 2, 2011 | Rockets | 107 | Trailblazers | 111 |
| March | 3, 2011 | Hornets | 107 | Rockets | 110 |
| March | 4, 2011 | Rockets | 84 | Trailblazers | 106 |
| March | 8, 2011 | Rockets | 89 | Grizzlies | 106 |
| March | 9, 2011 | Rockets | 82 | Bulls | 93 |
| March | 12, 2011 | Rockets | 87 | Hawks | 91 |
| March | 14, 2011 | Rockets | 127 | Nuggets | 88 |
| March | 15, 2011 | Rockets | 91 | Wizards | 83 |
| March | 22, 2011 | Rockets | 90 | Jazz | 123 |
| March | 24, 2011 | Magic | 95 | Rockets | 104 |
| March | 27, 2011 | Rockets | 117 | Thunder | 125 |
| March | 30, 2011 | Rockets | 98 | Kings | 128 |
| April | 1, 2011 | Pelicans | 115 | Rockets | 104 |
| April | 2, 2011 | Wizards | 114 | Rockets | 101 |
| April | 3, 2011 | Rockets | 90 | Mavericks | 120 |
| April | 5, 2011 | Jazz | 126 | Rockets | 118 |
| April | 6, 2011 | Rockets | 96 | Thunder | 124 |
| April | 9, 2011 | Kings | 107 | Rockets | 91 |
| April | 10, 2011 | Rockets | 105 | Warriors | 99 |
| April | 16, 2011 | Rockets | 100 | Wolves | 87 |
| April | 17, 2011 | Rockets | 99 | Wolves | 110 |
| April | 19, 2011 | Wolves | 108 | Rockets | 96 |
| April | 20, 2011 | Suns | 96 | Rockets | 102 |
| April | 21, 2011 | Hawks | 125 | Rockets | 92 |
| April | 22, 2011 | Trailblazers | 77 | Rockets | 81 |
| April | 24, 2011 | Trailblazers | 95 | Rockets | 97 |
| April | 25, 2011 | Clippers | 99 | Rockets | 113 |
| April | 26, 2011 | Mavericks | 83 | Rockets | 102 |
| April | 28, 2011 | 76ers | 87 | Rockets | 122 |