| month | day | visitor | score | home | score |
|---|
| November | 2, 2015 | Rockets | 120 | Spurs | 99 |
| November | 5, 2015 | Spurs | 100 | Pelicans | 106 |
| November | 7, 2015 | Pacers | 108 | Spurs | 127 |
| November | 9, 2015 | Wolves | 116 | Spurs | 120 |
| November | 12, 2015 | Spurs | 82 | Thunder | 109 |
| November | 14, 2015 | Spurs | 94 | Magic | 124 |
| November | 17, 2015 | Spurs | 117 | Bulls | 121 |
| November | 19, 2015 | Lakers | 115 | Spurs | 120 |
| November | 20, 2015 | Spurs | 106 | Clippers | 112 |
| November | 23, 2015 | Nets | 94 | Spurs | 102 |
| November | 25, 2015 | Spurs | 89 | Wolves | 122 |
| November | 27, 2015 | Blazers | 97 | Spurs | 100 |
| November | 30, 2015 | Spurs | 97 | Kings | 105 |
| December | 1, 2015 | Nuggets | 122 | Spurs | 97 |
| December | 4, 2015 | Spurs | 110 | 76ers | 111 |
| December | 7, 2015 | Spurs | 115 | Wizards | 109 |
| December | 9, 2015 | Spurs | 105 | Knicks | 113 |
| December | 12, 2015 | Spurs | 120 | Rockets | 124 |
| December | 14, 2015 | Suns | 97 | Spurs | 101 |
| December | 16, 2015 | Pistons | 104 | Spurs | 99 |
| December | 18, 2015 | Spurs | 122 | Warriors | 127 |
| December | 21, 2015 | Spurs | 84 | Mavericks | 106 |
| December | 25, 2015 | Spurs | 114 | Lakers | 98 |
| December | 26, 2015 | Spurs | 97 | Jazz | 105 |
| December | 28, 2015 | Bucks | 112 | Spurs | 116 |
| December | 31, 2015 | Spurs | 105 | Clippers | 91 |
| January | 2, 2016 | Cavaliers | 112 | Spurs | 100 |
| January | 5, 2016 | Spurs | 100 | Hawks | 117 |
| January | 8, 2016 | Grizzlies | 111 | Spurs | 88 |
| January | 10, 2016 | Spurs | 125 | Warriors | 113 |
| January | 11, 2016 | Rockets | 96 | Spurs | 116 |
| January | 13, 2016 | Spurs | 95 | Bucks | 116 |
| January | 15, 2016 | Spurs | 109 | Celtics | 119 |
| January | 17, 2016 | Jazz | 110 | Spurs | 108 |
| January | 18, 2016 | Spurs | 132 | Suns | 119 |
| January | 20, 2016 | Thunder | 99 | Spurs | 103 |
| January | 21, 2016 | Knicks | 99 | Spurs | 106 |
| January | 24, 2016 | Spurs | 109 | Lakers | 100 |
| January | 26, 2016 | Magic | 114 | Spurs | 99 |
| January | 29, 2016 | Suns | 121 | Spurs | 119 |
| February | 1, 2016 | Spurs | 110 | Blazers | 98 |
| February | 4, 2016 | 76ers | 121 | Spurs | 130 |
| February | 7, 2016 | Spurs | 142 | Wolves | 110 |
| February | 14, 2016 | Hawks | 93 | Spurs | 98 |
| February | 17, 2016 | Spurs | 96 | Kings | 100 |
| February | 19, 2016 | Pelicans | 101 | Spurs | 88 |
| February | 21, 2016 | Spurs | 106 | Heat | 121 |
| February | 24, 2016 | Spurs | 128 | Nets | 113 |
| February | 27, 2016 | Spurs | 123 | Rockets | 103 |
| March | 2, 2016 | Kings | 104 | Spurs | 105 |
| March | 4, 2016 | Spurs | 74 | Raptors | 102 |
| March | 5, 2016 | Celtics | 109 | Spurs | 114 |
| March | 7, 2016 | Spurs | 117 | Suns | 104 |
| March | 9, 2016 | Bulls | 101 | Spurs | 120 |
| March | 11, 2016 | Spurs | 97 | Nuggets | 104 |
| March | 12, 2016 | Grizzlies | 116 | Spurs | 113 |
| March | 14, 2016 | Spurs | 127 | Pistons | 108 |
| March | 15, 2016 | Lakers | 86 | Spurs | 101 |
| March | 18, 2016 | Thunder | 114 | Spurs | 130 |
| March | 20, 2016 | Wolves | 97 | Spurs | 108 |
| March | 23, 2016 | Spurs | 107 | Jazz | 112 |
| March | 24, 2016 | Raptors | 90 | Spurs | 96 |
| March | 26, 2016 | Wizards | 108 | Spurs | 103 |
| March | 27, 2016 | Spurs | 114 | Hornets | 94 |
| March | 29, 2016 | Pelicans | 88 | Spurs | 114 |
| March | 31, 2016 | Spurs | 134 | Pacers | 128 |
| April | 2, 2016 | Spurs | 112 | Cavaliers | 124 |
| April | 4, 2016 | Heat | 110 | Spurs | 117 |
| April | 6, 2016 | Blazers | 113 | Spurs | 111 |
| April | 9, 2016 | Clippers | 92 | Spurs | 113 |
| April | 10, 2016 | Nuggets | 95 | Spurs | 119 |
| April | 13, 2016 | Mavericks | 106 | Spurs | 104 |
| April | 16, 2016 | Spurs | 115 | Blazers | 112 |
| April | 18, 2016 | Warriors | 86 | Spurs | 129 |
| April | 19, 2016 | Hornets | 123 | Spurs | 117 |
| April | 21, 2016 | Spurs | 88 | Grizzlies | 97 |
| April | 22, 2016 | Jazz | 98 | Spurs | 108 |
| April | 24, 2016 | Kings | 90 | Spurs | 100 |
| April | 26, 2016 | Spurs | 103 | Pelicans | 90 |
| April | 29, 2016 | Spurs | 104 | Mavericks | 113 |
| April | 30, 2016 | Spurs | 125 | Grizzlies | 109 |
| May | 1, 2016 | Clippers | 107 | Spurs | 129 |
| Post | 1, 2016 | Spurs | 123 | Thunder | 105 |
| Post | 2, 2016 | Spurs | 94 | Thunder | 124 |
| Post | 3, 2016 | Thunder | 117 | Spurs | 114 |
| Post | 4, 2016 | Thunder | 104 | Spurs | 94 |
| Post | 5, 2016 | Spurs | 111 | Thunder | 107 |
| Post | 6, 2016 | Thunder | 103 | Spurs | 132 |
| Post | 7, 2016 | Spurs | 109 | Thunder | 116 |